RG9MTD2

RNA (guanine-9-) methyltransferase domain containing 2 is a protein that in humans is encoded by the RG9MTD2 gene.[1] The gene is also known as TRM10.[1]

Model organisms

Model organisms have been used in the study of RG9MTD2 function. A conditional knockout mouse line, called Rg9mtd2tm1a(EUCOMM)Wtsi[5][6] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[7][8][9]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[3][10] Twenty one tests were carried out on homozygous mutant mice and one significant abnormality was observed: males had increased circulating magnesium levels.[3]

References

  1. "RNA (guanine-9-) methyltransferase domain containing 2". Retrieved 2011-12-06.
  2. "Clinical chemistry data for Rg9mtd2". Wellcome Trust Sanger Institute.
  3. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  4. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  5. "International Knockout Mouse Consortium".
  6. "Mouse Genome Informatics".
  7. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  8. Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  9. Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  10. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.


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