RGS13

Regulator of G-protein signaling 13 (RGS13) is a protein that in humans is encoded by the RGS13 gene.[5][6]

RGS13
Identifiers
AliasesRGS13, regulator of G protein signaling 13
External IDsOMIM: 607190 MGI: 2180585 HomoloGene: 14774 GeneCards: RGS13
Orthologs
SpeciesHumanMouse
Entrez

6003

246709

Ensembl

ENSG00000127074

ENSMUSG00000051079

UniProt

O14921

Q8K443

RefSeq (mRNA)

NM_144766
NM_002927

NM_153171

RefSeq (protein)

NP_002918
NP_658912

NP_694811

Location (UCSC)Chr 1: 192.64 – 192.66 MbChr 1: 144.01 – 144.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RGS13 is a member of R4 subfamily of the Regulator of G protein signaling (RGS) protein family, whose members have only short peptide sequences flanking the RGS domain. RGS13 suppresses the immunoglobulin E- mediated allergic responses.[7]

RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000127074 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000051079 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Johnson EN, Druey KM (May 2002). "Functional characterization of the G protein regulator RGS13". J Biol Chem. 277 (19): 16768–16774. doi:10.1074/jbc.M200751200. PMID 11875076.
  6. "Entrez Gene: RGS13 regulator of G-protein signalling 13".
  7. Bansal G, Xie Z, Rao S, Nocka KH, Druey KM (2008). "Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13". Nat. Immunol. 9 (1): 73–80. doi:10.1038/ni1533. PMC 2387203. PMID 18026105.

Further reading


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