RHOQ

Rho-related GTP-binding protein RhoQ is a protein that in humans is encoded by the RHOQ gene.[5][6]

RHOQ
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRHOQ, ARHQ, HEL-S-42, RASL7A, TC10, TC10A, ras homolog family member Q
External IDsOMIM: 605857 MGI: 1931553 HomoloGene: 22704 GeneCards: RHOQ
Orthologs
SpeciesHumanMouse
Entrez

23433

104215

Ensembl

ENSG00000119729

ENSMUSG00000024143

UniProt

P17081

Q8R527

RefSeq (mRNA)

NM_012249

NM_145491

RefSeq (protein)

NP_036381

NP_663466

Location (UCSC)Chr 2: 46.54 – 46.58 MbChr 17: 87.27 – 87.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TC10 is a member of the RAS superfamily of small GTP-binding proteins (see HRAS, MIM 190020) involved in insulin-stimulated glucose uptake.[supplied by OMIM][6]

In melanocytic cells RHOQ gene expression may be regulated by MITF.[7]

Interactions

RHOQ has been shown to interact with EXOC7,[8] GOPC,[9] PARD6B,[9][10] WASL,[11] CDC42EP2,[12] TRIP10[13] and CDC42EP3.[12]

References

  1. GRCh38: Ensembl release 89: ENSG00000119729 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024143 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P (May 1990). "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line". Mol Cell Biol. 10 (4): 1793–8. doi:10.1128/mcb.10.4.1793. PMC 362288. PMID 2108320.
  6. "Entrez Gene: RHOQ ras homolog gene family, member Q".
  7. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
  8. Inoue, Mayumi; Chang Louise; Hwang Joseph; Chiang Shian-Huey; Saltiel Alan R (April 2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin" (PDF). Nature. England. 422 (6932): 629–33. Bibcode:2003Natur.422..629I. doi:10.1038/nature01533. hdl:2027.42/62982. ISSN 0028-0836. PMID 12687004. S2CID 4395760.
  9. Neudauer, C L; Joberty G; Macara I G (January 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. United States. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. ISSN 0006-291X. PMID 11162552.
  10. Joberty, G; Petersen C; Gao L; Macara I G (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. ENGLAND. 2 (8): 531–9. doi:10.1038/35019573. ISSN 1465-7392. PMID 10934474. S2CID 27139234.
  11. Abe, Tomoyuki; Kato Masayoshi; Miki Hiroaki; Takenawa Tadaomi; Endo Takeshi (January 2003). "Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth". J. Cell Sci. England. 116 (Pt 1): 155–68. doi:10.1242/jcs.00208. ISSN 0021-9533. PMID 12456725.
  12. Joberty, G; Perlungher R R; Macara I G (October 1999). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. UNITED STATES. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. ISSN 0270-7306. PMC 84628. PMID 10490598.
  13. Chang, Louise; Adams Rachael D; Saltiel Alan R (October 2002). "The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes". Proc. Natl. Acad. Sci. U.S.A. United States. 99 (20): 12835–40. Bibcode:2002PNAS...9912835C. doi:10.1073/pnas.202495599. ISSN 0027-8424. PMC 130546. PMID 12242347.

Further reading

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