RIC8A

RIC8A
Identifiers
Aliases	RIC8A, RIC8, RIC8 guanine nucleotide exchange factor A
External IDs	OMIM: 609146 MGI: 2141866 HomoloGene: 23331 GeneCards: RIC8A
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	215,113 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	140,444,285 bp[2]
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ganglionic eminence; ; smooth muscle tissue; ; gallbladder; ; anterior pituitary; ; prefrontal cortex; ; right coronary artery; ; left uterine tube; ; thoracic aorta; ; ascending aorta;
	Top expressed in
	Paneth cell; ; aortic valve; ; supraoptic nucleus; ; external carotid artery; ; fossa; ; ascending aorta; ; internal carotid artery; ; condyle; ; conjunctival fornix; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; G-protein alpha-subunit binding;
Cellular component	cytoplasm; plasma membrane; membrane;
Biological process	visual learning; G protein-coupled receptor signaling pathway; positive regulation of GTPase activity; cell migration involved in gastrulation; cell-cell adhesion involved in gastrulation; vasculature development; in utero embryonic development; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; gastrulation; response to light stimulus; basement membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	60626
	101489
	ENSG00000177963
	ENSMUSG00000025485
	Q9NPQ8
	Q3TIR3
	NM_001286134; NM_021932; NM_001386941; NM_001386942
	NM_053194
	NP_001273063; NP_068751
	NP_444424
	Wikidata
View/Edit Human	View/Edit Mouse

Resistance to inhibitors of cholinesterase-8A (Ric-8A), also known as Synembryn-A, is a protein that in humans is encoded by the RIC8A gene.[5][6][7]

Interactions

RIC8A has been shown to interact with GNAO1,[8] GNA13,[9][8] GNAQ,[8][10] GNAS complex locus,[10] GNAI2,[8] GNAI1[8] and GNAI3.[8]

References

GRCh38: Ensembl release 89: ENSG00000177963 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025485 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Miller KG, Emerson MD, McManus JR, Rand JB (Sep 2000). "RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system". Neuron. 27 (2): 289–99. doi:10.1016/S0896-6273(00)00037-4. PMC 4704990. PMID 10985349.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
"Entrez Gene: RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)".
Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. United States. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430.
Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY (September 2011). "Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization". The Journal of Biological Chemistry. 286 (35): 31055–61. doi:10.1074/jbc.M111.253427. PMC 3162464. PMID 21771786.
Klattenhoff, Carla; Montecino Martín; Soto Ximena; Guzmán Leonardo; Romo Ximena; García María Angeles; Mellstrom Britt; Naranjo José Ramón; Hinrichs María Victoria; Olate Juan (May 2003). "Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol". J. Cell. Physiol. United States. 195 (2): 151–7. doi:10.1002/jcp.10300. hdl:10533/174200. ISSN 0021-9541. PMID 12652642. S2CID 84975473.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tall GG, Krumins AM, Gilman AG (2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.
Klattenhoff C, Montecino M, Soto X, et al. (2003). "Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol". J. Cell. Physiol. 195 (2): 151–7. doi:10.1002/jcp.10300. hdl:10533/174200. PMID 12652642. S2CID 84975473.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Nishimura A, Okamoto M, Sugawara Y, et al. (2006). "Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells". Genes Cells. 11 (5): 487–98. doi:10.1111/j.1365-2443.2006.00959.x. PMID 16629901. S2CID 27425469.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Wang SC, Lai HL, et al. (2007). "Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor". Biochem J. 406 (3): 383–8. doi:10.1042/BJ20070512. PMC 2049038. PMID 17593019.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177963 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025485 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10985349-5] Miller KG, Emerson MD, McManus JR, Rand JB (Sep 2000). "RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system". Neuron. 27 (2): 289–99. doi:10.1016/S0896-6273(00)00037-4. PMC 4704990. PMID 10985349.

[pmid11230166-6] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-7] "Entrez Gene: RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)".

[pmid12509430-8] Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. United States. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430.

[pmid21771786-9] Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY (September 2011). "Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization". The Journal of Biological Chemistry. 286 (35): 31055–61. doi:10.1074/jbc.M111.253427. PMC 3162464. PMID 21771786.

[pmid12652642-10] Klattenhoff, Carla; Montecino Martín; Soto Ximena; Guzmán Leonardo; Romo Ximena; García María Angeles; Mellstrom Britt; Naranjo José Ramón; Hinrichs María Victoria; Olate Juan (May 2003). "Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol". J. Cell. Physiol. United States. 195 (2): 151–7. doi:10.1002/jcp.10300. hdl:10533/174200. ISSN 0021-9541. PMID 12652642. S2CID 84975473.

RIC8A

Interactions

References

Further reading