RILP (gene)

RILP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YHN
Identifiers
Aliases	RILP, PP10141, Rab interacting lysosomal protein
External IDs	OMIM: 607848 MGI: 2144271 HomoloGene: 19596 GeneCards: RILP
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	1,649,866 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	75,403,994 bp[2]
RNA expression pattern
	Top expressed in
	left ventricle; ; right lobe of thyroid gland; ; gastrocnemius muscle; ; left lobe of thyroid gland; ; blood; ; skeletal muscle tissue; ; right lobe of liver; ; duodenum; ; right lung; ; subcutaneous adipose tissue;
	Top expressed in
	interventricular septum; ; soleus muscle; ; myocardium of ventricle; ; knee joint; ; quadriceps femoris muscle; ; digastric muscle; ; sternocleidomastoid muscle; ; tibialis anterior muscle; ; skeletal muscle tissue; ; triceps brachii muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	dynein light intermediate chain binding; protein binding; small GTPase binding; protein dimerization activity;
Cellular component	endosome; late endosome; phagocytic vesicle membrane; membrane; late endosome membrane; lysosomal membrane; lysosome; cytoplasmic vesicle; cytosol; ciliary basal body; protein-containing complex; cytoplasm;
Biological process	positive regulation of protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; endosome transport via multivesicular body sorting pathway; negative regulation of protein catabolic process; endosome to lysosome transport; early endosome to late endosome transport; intralumenal vesicle formation; regulation of multivesicular body size; protein transport; cilium assembly;
	Sources:Amigo / QuickGO
Orthologs
	83547
	280408
	ENSG00000274145; ENSG00000167705
	ENSMUSG00000038195
	Q96NA2
	Q5ND29
	NM_031430
	NM_001029938
	NP_113618
	NP_001025109
	Wikidata
View/Edit Human	View/Edit Mouse

Rab-interacting lysosomal protein is a protein that in humans is encoded by the RILP gene.[5][6]

Function

RILP, along with the GTPase RAB7 (MIM 602298), controls late endocytic transport.[supplied by OMIM][6]

Interactions

RILP (gene) has been shown to interact with RAB7A.[5][7]

References

ENSG00000167705 GRCh38: Ensembl release 89: ENSG00000274145, ENSG00000167705 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038195 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Cantalupo G, Alifano P, Roberti V, Bruni CB, Bucci C (February 2001). "Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes". EMBO J. 20 (4): 683–93. doi:10.1093/emboj/20.4.683. PMC 145419. PMID 11179213.
"Entrez Gene: RILP Rab interacting lysosomal protein".
Caplan S, Hartnell LM, Aguilar RC, Naslavsky N, Bonifacino JS (July 2001). "Human Vam6p promotes lysosome clustering and fusion in vivo". J. Cell Biol. 154 (1): 109–22. doi:10.1083/jcb.200102142. PMC 2196876. PMID 11448994.

Bucci C, De Gregorio L, Bruni CB (2001). "Expression analysis and chromosomal assignment of PRA1 and RILP genes". Biochem. Biophys. Res. Commun. 286 (4): 815–9. doi:10.1006/bbrc.2001.5466. PMID 11520070.
Jordens I, Fernandez-Borja M, Marsman M, Dusseljee S, Janssen L, Calafat J, Janssen H, Wubbolts R, Neefjes J (2002). "The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors". Curr. Biol. 11 (21): 1680–5. doi:10.1016/S0960-9822(01)00531-0. PMID 11696325. S2CID 14642826.
Wang T, Hong W (2003). "Interorganellar Regulation of Lysosome Positioning by the Golgi Apparatus through Rab34 Interaction with Rab-interacting Lysosomal Protein". Mol. Biol. Cell. 13 (12): 4317–32. doi:10.1091/mbc.E02-05-0280. PMC 138636. PMID 12475955.
Cardoso C, Leventer RJ, Ward HL, Toyo-Oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB, Ledbetter DH (2003). "Refinement of a 400-kb Critical Region Allows Genotypic Differentiation between Isolated Lissencephaly, Miller-Dieker Syndrome, and Other Phenotypes Secondary to Deletions of 17p13.3". Am. J. Hum. Genet. 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583.
Harrison RE, Bucci C, Vieira OV, Schroer TA, Grinstein S (2003). "Phagosomes Fuse with Late Endosomes and/or Lysosomes by Extension of Membrane Protrusions along Microtubules: Role of Rab7 and RILP". Mol. Cell. Biol. 23 (18): 6494–506. doi:10.1128/MCB.23.18.6494-6506.2003. PMC 193691. PMID 12944476.
Wang T, Wong KK, Hong W (2004). "A Unique Region of RILP Distinguishes It from Its Related Proteins in Its Regulation of Lysosomal Morphology and Interaction with Rab7 and Rab34". Mol. Biol. Cell. 15 (2): 815–26. doi:10.1091/mbc.E03-06-0413. PMC 329395. PMID 14668488.
Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Wu M, Wang T, Loh E, Hong W, Song H (2005). "Structural basis for recruitment of RILP by small GTPase Rab7". EMBO J. 24 (8): 1491–501. doi:10.1038/sj.emboj.7600643. PMC 1142575. PMID 15933719.
Colucci AM, Campana MC, Bellopede M, Bucci C (2005). "The Rab-interacting lysosomal protein, a Rab7 and Rab34 effector, is capable of self-interaction". Biochem. Biophys. Res. Commun. 334 (1): 128–33. doi:10.1016/j.bbrc.2005.06.067. PMID 15996637.
Shimojo M, Hersh LB (2006). "Characterization of the REST/NRSF-interacting LIM domain protein (RILP): localization and interaction with REST/NRSF". J. Neurochem. 96 (4): 1130–8. doi:10.1111/j.1471-4159.2005.03608.x. PMID 16417580. S2CID 6893975.
Marsman M, Jordens I, Rocha N, Kuijl C, Janssen L, Neefjes J (2006). "A splice variant of RILP induces lysosomal clustering independent of dynein recruitment". Biochem. Biophys. Res. Commun. 344 (3): 747–56. doi:10.1016/j.bbrc.2006.03.178. PMID 16631113.
Progida C, Spinosa MR, De Luca A, Bucci C (2006). "RILP interacts with the VPS22 component of the ESCRT-II complex". Biochem. Biophys. Res. Commun. 347 (4): 1074–9. doi:10.1016/j.bbrc.2006.07.007. PMID 16857164.

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[refGRCh38Ensembl-1] ENSG00000167705 GRCh38: Ensembl release 89: ENSG00000274145, ENSG00000167705 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038195 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11179213-5] Cantalupo G, Alifano P, Roberti V, Bruni CB, Bucci C (February 2001). "Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes". EMBO J. 20 (4): 683–93. doi:10.1093/emboj/20.4.683. PMC 145419. PMID 11179213.

[entrez-6] "Entrez Gene: RILP Rab interacting lysosomal protein".

[pmid11448994-7] Caplan S, Hartnell LM, Aguilar RC, Naslavsky N, Bonifacino JS (July 2001). "Human Vam6p promotes lysosome clustering and fusion in vivo". J. Cell Biol. 154 (1): 109–22. doi:10.1083/jcb.200102142. PMC 2196876. PMID 11448994.

RILP (gene)

Function

Interactions

References

Further reading