RNA polymerase II subunit B4

DNA-directed RNA polymerase II subunit RPB4 is an enzyme that in humans is encoded by the POLR2D gene.[5]

POLR2D
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLR2D, HSRBP4, HSRPB4, RBP4, RPB16, RNA polymerase II subunit B4, polymerase (RNA) II subunit D, RNA polymerase II subunit D, RPB4
External IDsOMIM: 606017 MGI: 1916491 HomoloGene: 37968 GeneCards: POLR2D
Orthologs
SpeciesHumanMouse
Entrez

5433

69241

Ensembl

ENSG00000144231

ENSMUSG00000024258

UniProt

O15514

Q9D7M8

RefSeq (mRNA)

NM_004805

NM_027002
NM_001357480

RefSeq (protein)

NP_004796

NP_081278
NP_001344409

Location (UCSC)Chr 2: 127.84 – 127.86 MbChr 18: 31.92 – 31.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes the fourth-largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000144231 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024258 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Khazak V, Estojak J, Cho H, Majors J, Sonoda G, Testa JR, Golemis EA (May 1998). "Analysis of the interaction of the novel RNA polymerase II (pol II) subunit hsRPB4 with its partner hsRPB7 and with pol II". Mol Cell Biol. 18 (4): 1935–45. doi:10.1128/mcb.18.4.1935. PMC 121423. PMID 9528765.
  6. "Entrez Gene: POLR2D polymerase (RNA) II (DNA directed) polypeptide D".

Further reading

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