RNF10

RING finger protein 10 is a protein that in humans is encoded by the RNF10 gene.[5]

RNF10
Identifiers
AliasesRNF10, RIE2, ring finger protein 10
External IDsOMIM: 615998 MGI: 1859162 HomoloGene: 40990 GeneCards: RNF10
Orthologs
SpeciesHumanMouse
Entrez

9921

50849

Ensembl

ENSG00000022840

ENSMUSG00000041740

UniProt

Q8N5U6

Q3UIW5

RefSeq (mRNA)

NM_014868
NM_001330474

NM_016698
NM_001302448
NM_001302449

RefSeq (protein)

NP_001317403
NP_055683

NP_001289377
NP_001289378
NP_057907

Location (UCSC)Chr 12: 120.53 – 120.58 MbChr 5: 115.38 – 115.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known.[5]

Model organisms

Model organisms have been used in the study of RNF10 function. A conditional knockout mouse line, called Rnf10tm1a(KOMP)Wtsi[14][15] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[16][17][18]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[12][19] Twenty two tests were carried out on mutant mice and five significant abnormalities were observed.[12] Homozygous mutant animals displayed increased chromosomal stability in a micronucleus test. Females also had increased body weight, an increased amount of total body fat and an abnormal complete blood count. Males additionally displayed an increase in eating behavior.[12]

References

  1. GRCh38: Ensembl release 89: ENSG00000022840 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041740 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: RNF10 ring finger protein 10".
  6. "Body weight data for Rnf10". Wellcome Trust Sanger Institute.
  7. "Indirect calorimetry data for Rnf10". Wellcome Trust Sanger Institute.
  8. "DEXA data for Rnf10". Wellcome Trust Sanger Institute.
  9. "Haematology data for Rnf10". Wellcome Trust Sanger Institute.
  10. "Salmonella infection data for Rnf10". Wellcome Trust Sanger Institute.
  11. "Citrobacter infection data for Rnf10". Wellcome Trust Sanger Institute.
  12. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  13. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  14. "International Knockout Mouse Consortium".
  15. "Mouse Genome Informatics".
  16. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  17. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  18. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  19. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

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