RNF123

E3 ubiquitin-protein ligase RNF123 is an enzyme that in humans is encoded by the RNF123 gene.[5]

RNF123
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNF123, KPC1, FP1477, ring finger protein 123
External IDsOMIM: 614472 MGI: 2148796 HomoloGene: 11112 GeneCards: RNF123
Orthologs
SpeciesHumanMouse
Entrez

63891

84585

Ensembl

ENSG00000164068

ENSMUSG00000041528

UniProt

Q5XPI4

Q5XPI3

RefSeq (mRNA)

NM_022064

NM_032543
NM_001311152

RefSeq (protein)

NP_071347

NP_001298081
NP_115932

Location (UCSC)Chr 3: 49.69 – 49.72 MbChr 9: 107.93 – 107.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions.[5] Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1 (Chaturvedi et al, 2012, PMID: 23077635).

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000164068 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041528 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: RNF123 ring finger protein 123".

Further reading


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