RNF135

RING finger protein 135 is a protein that in humans is encoded by the RNF135 gene.[5][6][7]

RNF135
Identifiers
AliasesRNF135, MMFD, REUL, Riplet, L13, ring finger protein 135
External IDsOMIM: 611358 MGI: 1919206 HomoloGene: 12427 GeneCards: RNF135
Orthologs
SpeciesHumanMouse
Entrez

84282

71956

Ensembl

ENSG00000181481

ENSMUSG00000020707

UniProt

Q8IUD6

Q9CWS1

RefSeq (mRNA)

NM_001184992
NM_032322
NM_197939

NM_028019

RefSeq (protein)

NP_001171921
NP_115698
NP_922921

NP_082295

Location (UCSC)Chr 17: 30.97 – 31 MbChr 11: 80.07 – 80.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]

Interactions

RNF135 has been shown to interact with RARRES3.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000181481 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020707 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jenne DE, Tinschert S, Reimann H, Lasinger W, Thiel G, Hameister H, Kehrer-Sawatzki H (Aug 2001). "Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions". Am J Hum Genet. 69 (3): 516–27. doi:10.1086/323043. PMC 1235482. PMID 11468690.
  6. Oshiumi H, Matsumoto M, Hatakeyama S, Seya T (Jan 2009). "Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection". J Biol Chem. 284 (2): 807–17. doi:10.1074/jbc.M804259200. PMID 19017631.
  7. "Entrez Gene: RNF135 ring finger protein 135".

Further reading


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