RNF41

E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.[5]

RNF41
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNF41, FLRF, NRDP1, SBBI03, ring finger protein 41
External IDsMGI: 1914838 HomoloGene: 4226 GeneCards: RNF41
Orthologs
SpeciesHumanMouse
Entrez

10193

67588

Ensembl

ENSG00000181852

ENSMUSG00000025373

UniProt

Q9H4P4

Q8BH75

RefSeq (mRNA)

NM_001242826
NM_005785
NM_194358
NM_194359

NM_001164237
NM_026259

RefSeq (protein)

NP_001229755
NP_005776
NP_919339
NP_919340

NP_001157709
NP_080535

Location (UCSC)Chr 12: 56.2 – 56.22 MbChr 10: 128.25 – 128.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.[5]

Interactions

RNF41 has been shown to interact with USP8.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000181852 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025373 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: RNF41 ring finger protein 41".
  6. Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.

Further reading


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