RNF5

E3 ubiquitin-protein ligase RNF5 is an enzyme that in humans is encoded by the RNF5 gene.[5][6]

RNF5
Identifiers
AliasesRNF5, RING5, RMA1, ring finger protein 5
External IDsOMIM: 602677 MGI: 1860076 HomoloGene: 56004 GeneCards: RNF5
Orthologs
SpeciesHumanMouse
Entrez

6048

54197

Ensembl

ENSMUSG00000015478

UniProt

Q99942

O35445

RefSeq (mRNA)

NM_006913

NM_019403

RefSeq (protein)

NP_008844

NP_062276

Location (UCSC)Chr 6: 32.18 – 32.18 MbChr 17: 34.82 – 34.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions.[6]

References

  1. ENSG00000223767, ENSG00000228907, ENSG00000183574, ENSG00000204308, ENSG00000225452, ENSG00000228405 GRCh38: Ensembl release 89: ENSG00000227277, ENSG00000223767, ENSG00000228907, ENSG00000183574, ENSG00000204308, ENSG00000225452, ENSG00000228405 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000015478 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kyushiki H, Kuga Y, Suzuki M, Takahashi E, Horie M (Apr 1998). "Cloning, expression and mapping of a novel RING-finger gene (RNF5), a human homologue of a putative zinc-finger gene from Caenorhabditis elegans". Cytogenetics and Cell Genetics. 79 (1–2): 114–7. doi:10.1159/000134695. PMID 9533025.
  6. "Entrez Gene: RNF5 ring finger protein 5".

Further reading

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