RNase E 5′ UTR element
In molecular biology, the RNase E 5′ UTR element is a cis-acting element located in the 5′ UTR of ribonuclease (RNase) E messenger RNA (mRNA).
| RNase E 5′ UTR element | |
|---|---|
 Predicted secondary structure and sequence conservation of rne5 | |
| Identifiers | |
| Symbol | rne5 |
| Rfam | RF00040 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Bacteria |
| SO | SO:0000204 |
| PDB structures | PDBe |
RNase E is a key regulatory enzyme in the pathway of mRNA degradation in Escherichia coli. It is able to auto-regulate the degradation of its own mRNA in response to changes in RNase E activity. This rne 5′ UTR element acts as a sensor of cellular RNase E concentration enabling tight regulation of RNase E concentration and synthesis.[1]
See also
References
- Diwa A, Bricker AL, Jain C, Belasco JG (2000). "An evolutionarily conserved RNA stem–loop functions as a sensor that directs feedback regulation of RNase E gene expression". Genes Dev. 14 (10): 1249–1260. doi:10.1101/gad.14.10.1249. PMC 316614. PMID 10817759.
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