RNASET2

RNASET2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3T0O
Identifiers
Aliases	RNASET2, RNASE6PL, bA514O12.3, ribonuclease T2
External IDs	OMIM: 612944 MGI: 3702087 HomoloGene: 31190 GeneCards: RNASET2
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	166,957,191 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	7,278,698 bp[2]
RNA expression pattern
	Top expressed in
	right uterine tube; ; blood; ; monocyte; ; spleen; ; parotid gland; ; seminal vesicula; ; olfactory bulb; ; lymph node; ; inferior ganglion of vagus nerve; ; periodontal fiber;
	Top expressed in
	lip; ; esophagus; ; morula; ; superior frontal gyrus; ; yolk sac; ; secondary oocyte; ; spermatid; ; proximal tubule; ; mirror; ; thymus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; ribonuclease T2 activity; endonuclease activity; nuclease activity; RNA binding; ribonuclease activity; endoribonuclease activity;
Cellular component	lysosomal lumen; endoplasmic reticulum lumen; lysosome; endoplasmic reticulum; extracellular exosome; extracellular region; extracellular space; azurophil granule lumen;
Biological process	nucleic acid phosphodiester bond hydrolysis; RNA phosphodiester bond hydrolysis, endonucleolytic; RNA catabolic process; RNA phosphodiester bond hydrolysis; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	8635
	68195
	ENSG00000026297
	ENSMUSG00000094724
	O00584
	Q5FWA0
	NM_003730; NM_017795; NM_018726
	NM_026611; NM_029204
	NP_003721
	NP_080887; NP_001077407; NP_080887
	Wikidata
View/Edit Human	View/Edit Mouse

Ribonuclease T2 is an enzyme that in humans is encoded by the RNASET2 gene.[5][6] It is a type of endoribonuclease.

This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement.[6] RNASET2 has been reported as a tumour associated antigen in anaplastic large cell lymphoma and other lymphomas.[7]

References

GRCh38: Ensembl release 89: ENSG00000026297 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000094724 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Trubia M, Sessa L, Taramelli R (Sep 1997). "Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies". Genomics. 42 (2): 342–344. doi:10.1006/geno.1997.4679. PMID 9192857.
"Entrez Gene: RNASET2 ribonuclease T2".
Patel S, Chen H, Monti L, Gould E, Haralambieva E, Schmid J, Toomey D, Woessmann W, Roncador G, Hatton CS, Liggins AP, Taramelli R, Banham AH, Acquati F, Murphy D, Pulford K (Sep 2012). "RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis". J Proteomics. 75 (17): 5279–5292. doi:10.1016/j.jprot.2012.06.009. PMID 22732457.

Acquati F, Morelli C, Cinquetti R, et al. (2001). "Cloning and characterization of a senescence inducing and class II tumor suppressor gene in ovarian carcinoma at chromosome region 6q27". Oncogene. 20 (8): 980–988. doi:10.1038/sj.onc.1204178. PMID 11314033.
Liu Y, Emilion G, Mungall AJ, et al. (2002). "Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer". Oncogene. 21 (3): 387–399. doi:10.1038/sj.onc.1205067. PMID 11821951.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Acquati F, Possati L, Ferrante L, et al. (2005). "Tumor and metastasis suppression by the human RNASET2 gene". Int. J. Oncol. 26 (5): 1159–68. doi:10.3892/ijo.26.5.1159. PMID 15809705.
Campomenosi P, Salis S, Lindqvist C, et al. (2006). "Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins". Arch. Biochem. Biophys. 449 (1–2): 17–26. doi:10.1016/j.abb.2006.02.022. PMID 16620762.
Patel S, Chen H, Monti L, Gould E, Haralambieva E, Schmid J, Toomey D, Woessmann W, Roncador G, Hatton CS, Liggins AP, Taramelli R, Banham AH, Acquati F, Murphy D, Pulford K (2012). "RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis". J Proteomics. 75 (17): 5279–5292. doi:10.1016/j.jprot.2012.06.009. PMID 22732457.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000026297 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000094724 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9192857-5] Trubia M, Sessa L, Taramelli R (Sep 1997). "Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies". Genomics. 42 (2): 342–344. doi:10.1006/geno.1997.4679. PMID 9192857.

[entrez-6] "Entrez Gene: RNASET2 ribonuclease T2".

[pmid22732457-7] Patel S, Chen H, Monti L, Gould E, Haralambieva E, Schmid J, Toomey D, Woessmann W, Roncador G, Hatton CS, Liggins AP, Taramelli R, Banham AH, Acquati F, Murphy D, Pulford K (Sep 2012). "RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis". J Proteomics. 75 (17): 5279–5292. doi:10.1016/j.jprot.2012.06.009. PMID 22732457.

RNASET2

References

Further reading