ROCK2

ROCK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4L6Q, 4WOT
Identifiers
Aliases	ROCK2, ROCK-II, Rho associated coiled-coil containing protein kinase 2
External IDs	OMIM: 604002 MGI: 107926 HomoloGene: 21010 GeneCards: ROCK2
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	11,348,330 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	16,987,823 bp[2]
RNA expression pattern
	Top expressed in
	Achilles tendon; ; middle temporal gyrus; ; thoracic diaphragm; ; biceps brachii; ; superficial temporal artery; ; Brodmann area 10; ; cerebellar vermis; ; Brodmann area 46; ; rectum; ; deltoid muscle;
	Top expressed in
	aortic valve; ; ascending aorta; ; superior frontal gyrus; ; triceps brachii muscle; ; thoracic diaphragm; ; soleus muscle; ; plantaris muscle; ; vastus lateralis muscle; ; primary motor cortex; ; knee joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; structural molecule activity; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; Rho-dependent protein serine/threonine kinase activity; RNA binding; tau protein binding; tau-protein kinase activity;
Cellular component	cytoplasm; centrosome; membrane; plasma membrane; microtubule organizing center; cytoplasmic ribonucleoprotein granule; cytoskeleton; nucleus; cytosol; intracellular anatomical structure;
Biological process	smooth muscle contraction; positive regulation of protein phosphorylation; intracellular signal transduction; regulation of actin cytoskeleton organization; centrosome duplication; phosphorylation; rhythmic process; ephrin receptor signaling pathway; cellular response to testosterone stimulus; cytokinesis; positive regulation of centrosome duplication; regulation of stress fiber assembly; regulation of cell motility; positive regulation of endothelial cell migration; protein phosphorylation; negative regulation of bicellular tight junction assembly; vascular endothelial growth factor receptor signaling pathway; positive regulation of gene expression; regulation of cell adhesion; regulation of circadian rhythm; Rho protein signal transduction; regulation of focal adhesion assembly; negative regulation of angiogenesis; regulation of keratinocyte differentiation; negative regulation of myosin-light-chain-phosphatase activity; I-kappaB kinase/NF-kappaB signaling; regulation of establishment of cell polarity; cortical actin cytoskeleton organization; regulation of establishment of endothelial barrier; actin cytoskeleton organization; protein localization to plasma membrane; G protein-coupled receptor signaling pathway; aortic valve morphogenesis; positive regulation of cardiac muscle hypertrophy; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of cell migration; positive regulation of connective tissue growth factor production; positive regulation of MAPK cascade; regulation of protein metabolic process; positive regulation of stress fiber assembly; negative regulation of biomineral tissue development; response to transforming growth factor beta; positive regulation of fibroblast growth factor production; regulation of angiotensin-activated signaling pathway; negative regulation of protein localization to lysosome; positive regulation of amyloid-beta formation; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; positive regulation of protein localization to early endosome; positive regulation of amyloid precursor protein catabolic process; positive regulation of connective tissue replacement; response to angiotensin; response to ischemia; negative regulation of gene expression; regulation of nervous system process; negative regulation of nitric oxide biosynthetic process; mRNA destabilization; blood vessel diameter maintenance; regulation of cellular response to hypoxia; cellular response to acetylcholine; mitotic cytokinesis; actomyosin structure organization; embryonic morphogenesis; regulation of cell junction assembly;
	Sources:Amigo / QuickGO
Orthologs
	9475
	19878
	ENSG00000134318
	ENSMUSG00000020580
	O75116
	P70336
	NM_004850; NM_001321643
	NM_009072
	NP_001308572; NP_004841
	NP_033098
	Wikidata
View/Edit Human	View/Edit Mouse

Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. [5]Fasudil is an inhibitor of ROCK protein.

Function

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

References

GRCh38: Ensembl release 89: ENSG00000134318 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020580 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Rho associated coiled-coil containing protein kinase 2". Retrieved 2016-04-21.

External links

Overview of all the structural information available in the PDB for UniProt: O75116 (Human Rho-associated protein kinase 2 (ROCK2)) at the PDBe-KB.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134318 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020580 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Rho associated coiled-coil containing protein kinase 2". Retrieved 2016-04-21.

ROCK2

Function

References

Further reading

External links