R-spondin 3

R-spondin-3 is a protein that in humans is encoded by the RSPO3 gene.[5][6][7]

RSPO3
Identifiers
AliasesRSPO3, CRISTIN1, PWTSR, THSD2, R-spondin 3
External IDsOMIM: 610574 MGI: 1920030 HomoloGene: 12484 GeneCards: RSPO3
Orthologs
SpeciesHumanMouse
Entrez

84870

72780

Ensembl

ENSG00000146374

ENSMUSG00000019880

UniProt

Q9BXY4

Q2TJ95

RefSeq (mRNA)

NM_032784

NM_028351

RefSeq (protein)

NP_116173

NP_082627

Location (UCSC)Chr 6: 127.12 – 127.2 MbChr 10: 29.33 – 29.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the thrombospondin type 1 repeat gene superfamily. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases.[7]

During embryonic development, RSPO3 is expressed in the tail bud and the posterior presomitic mesoderm of the embryo. In tissue engineering, R-spondin 3 has been used to differentiate pluripotent stem cells into paraxial mesoderm progenitors[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000146374 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019880 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Adams JC, Tucker RP (Jun 2000). "The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development". Developmental Dynamics. 218 (2): 280–99. doi:10.1002/(SICI)1097-0177(200006)218:2<280::AID-DVDY4>3.0.CO;2-0. PMID 10842357.
  6. Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W (Oct 2004). "R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis". Developmental Cell. 7 (4): 525–34. doi:10.1016/j.devcel.2004.07.019. PMID 15469841.
  7. "Entrez Gene: RSPO3 R-spondin 3 homolog (Xenopus laevis)".
  8. Chal J, Oginuma M, Al Tanoury Z, Gobert B, Sumara O, Hick A, Bousson F, Zidouni Y, Mursch C, Moncuquet P, Tassy O, Vincent S, Miyanari A, Bera A, Garnier JM, Guevara G, Hestin M, Kennedy L, Hayashi S, Drayton B, Cherrier T, Gayraud-Morel B, Gussoni E, Relaix F, Tajbakhsh S, Pourquié O (Sep 2015). "Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy". Nature Biotechnology. 33 (9): 962–9. doi:10.1038/nbt.3297. PMID 26237517. S2CID 21241434. closed access

Further reading


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