RTL3

Retrotransposon Gag like 3 is a protein that in humans is encoded by the RTL3 gene. [5]

RTL3
Identifiers
AliasesRTL3, Mar3, Mart3, ZHC5, ZCCHC5, zinc finger CCHC-type containing 5, SIRH9, retrotransposon Gag like 3
External IDsMGI: 2685221 HomoloGene: 19397 GeneCards: RTL3
Orthologs
SpeciesHumanMouse
Entrez

203430

213436

Ensembl

ENSG00000179300

ENSMUSG00000047686

UniProt

Q8N8U3

Q6P1Y1

RefSeq (mRNA)

NM_152694

NM_199468

RefSeq (protein)

NP_689907

NP_955762

Location (UCSC)Chr X: 78.66 – 78.66 MbChr X: 105.88 – 105.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell. Retrotransposon gag-like-3 (RTL3/ZCCHC5/MART3) is one of eleven Sushi-like neogenes identified in the human genome7 RTL3 encodes a 53 kDa protein with a nucleic acid-binding domain (CX2CX4HX4C), gag-like region within the open reading frame and an ssDNA/RNA-binding homeobox-associated leucine zipper motif.[6] It has been reported that RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes.[7]

References
  1. GRCh38: Ensembl release 89: ENSG00000179300 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000047686 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Retrotransposon Gag like 3". Retrieved 2017-09-18.
  6. Ball, Hope C.; Ansari, Mohammad Y.; Ahmad, Nashrah; Novak, Kimberly; Haqqi, Tariq M. (November 2021). "A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes". Connective Tissue Research. 62 (6): 615–628. doi:10.1080/03008207.2020.1828380. ISSN 1607-8438. PMC 8404968. PMID 33043724.
  7. Ball, Hope C.; Ansari, Mohammad Y.; Ahmad, Nashrah; Novak, Kimberly; Haqqi, Tariq M. (November 2021). "A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes". Connective Tissue Research. 62 (6): 615–628. doi:10.1080/03008207.2020.1828380. ISSN 1607-8438. PMC 8404968. PMID 33043724.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.