RTN2

RTN2
Identifiers
Aliases	RTN2, NSP2, NSPL1, NSPLI, SPG12, reticulon 2
External IDs	OMIM: 603183 MGI: 107612 HomoloGene: 32180 GeneCards: RTN2
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	45,497,055 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	19,030,085 bp[2]
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; vastus lateralis muscle; ; thoracic diaphragm; ; triceps brachii muscle; ; biceps brachii; ; body of tongue; ; deltoid muscle; ; tibialis anterior muscle; ; Brodmann area 10; ; spinal ganglia;
	Top expressed in
	triceps brachii muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; ankle; ; digastric muscle; ; extensor digitorum longus muscle; ; vastus lateralis muscle; ; tibialis anterior muscle; ; soleus muscle; ; plantaris muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; T-tubule; integral component of endoplasmic reticulum membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; terminal cisterna;
Biological process	intracellular protein transmembrane transport; regulation of glucose import;
	Sources:Amigo / QuickGO
Orthologs
	6253
	20167
	ENSG00000125744
	ENSMUSG00000030401
	O75298; Q96CG9
	O70622
	NM_206902; NM_005619; NM_206900; NM_206901
	NM_001025364; NM_013648
	NP_005610; NP_996783; NP_996784
	NP_001020535; NP_038676
	Wikidata
View/Edit Human	View/Edit Mouse

Reticulon-2 is a protein that in humans is encoded by the RTN2 gene.[5][6][7]

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

References

GRCh38: Ensembl release 89: ENSG00000125744 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030401 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Stubbs L, Carver EA, Shannon ME, Kim J, Geisler J, Generoso EE, Stanford BG, Dunn WC, Mohrenweiser H, Zimmermann W, Watt SM, Ashworth LK (Dec 1996). "Detailed comparative map of human chromosome 19q and related regions of the mouse genome". Genomics. 35 (3): 499–508. doi:10.1006/geno.1996.0390. PMID 8812484.
Geisler JG, Stubbs LJ, Wasserman WW, Mucenski ML (May 1998). "Molecular cloning of a novel mouse gene with predominant muscle and neural expression". Mamm Genome. 9 (4): 274–82. doi:10.1007/s003359900748. PMID 9530622. S2CID 7091637.
"Entrez Gene: RTN2 reticulon 2".

Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
He W, Lu Y, Qahwash I, et al. (2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation". Nat. Med. 10 (9): 959–65. doi:10.1038/nm1088. PMID 15286784. S2CID 23570406.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
Oertle T, Klinger M, Stuermer CA, Schwab ME (2003). "A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family". FASEB J. 17 (10): 1238–47. doi:10.1096/fj.02-1166hyp. PMID 12832288. S2CID 27903.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Geisler JG, Palmer RJ, Stubbs LJ, Mucenski ML (2000). "Nspl1, a new Z-band-associated protein". J. Muscle Res. Cell. Motil. 20 (7): 661–8. doi:10.1023/A:1005533013926. PMID 10672514. S2CID 26327921.
Roebroek AJ, Contreras B, Pauli IG, Van de Ven WJ (1998). "cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons". Genomics. 51 (1): 98–106. doi:10.1006/geno.1997.5175. PMID 9693037.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125744 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030401 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8812484-5] Stubbs L, Carver EA, Shannon ME, Kim J, Geisler J, Generoso EE, Stanford BG, Dunn WC, Mohrenweiser H, Zimmermann W, Watt SM, Ashworth LK (Dec 1996). "Detailed comparative map of human chromosome 19q and related regions of the mouse genome". Genomics. 35 (3): 499–508. doi:10.1006/geno.1996.0390. PMID 8812484.

[pmid9530622-6] Geisler JG, Stubbs LJ, Wasserman WW, Mucenski ML (May 1998). "Molecular cloning of a novel mouse gene with predominant muscle and neural expression". Mamm Genome. 9 (4): 274–82. doi:10.1007/s003359900748. PMID 9530622. S2CID 7091637.

[entrez-7] "Entrez Gene: RTN2 reticulon 2".

RTN2

References

Further reading