RUVBL2

RuvB-like 2 (E. coli), also known as RUVBL2, is a human gene coding for a protein belonging to the AAA+ family of proteins.

RUVBL2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRUVBL2, ECP51, INO80J, REPTIN, RVB2, TIH2, TIP48, TIP49B, CGI-46, ECP-51, TAP54-beta, RuvB like AAA ATPase 2
External IDsOMIM: 604788 MGI: 1342299 HomoloGene: 4856 GeneCards: RUVBL2
Orthologs
SpeciesHumanMouse
Entrez

10856

20174

Ensembl

ENSG00000183207

ENSMUSG00000003868

UniProt

Q9Y230

Q9WTM5

RefSeq (mRNA)

NM_006666
NM_001321190
NM_001321191

NM_011304

RefSeq (protein)

NP_001308119
NP_001308120
NP_006657

NP_035434

Location (UCSC)Chr 19: 48.99 – 49.02 MbChr 7: 45.07 – 45.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. However, the evidence for whether RUVBL2 has DNA helicase activity is contradictory.[5] This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.[6]

Interactions

RUVBL2 has been shown to interact with RuvB-like 1[7] and Activating transcription factor 2.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000183207 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003868 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Puri T, Wendler P, Sigala B, Saibil H, Tsaneva IR (Feb 2007). "Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex". Journal of Molecular Biology. 366 (1): 179–92. doi:10.1016/j.jmb.2006.11.030. PMID 17157868.
  6. "Entrez Gene: RUVBL2 RuvB-like 2 (E. coli)".
  7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  8. Cho SG, Bhoumik A, Broday L, Ivanov V, Rosenstein B, Ronai Z (Dec 2001). "TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage". Molecular and Cellular Biology. 21 (24): 8398–413. doi:10.1128/MCB.21.24.8398-8413.2001. PMC 100004. PMID 11713276.

Further reading


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