Ras p21 protein activator 2

RASA2
Identifiers
Aliases	RASA2, GAP1M, RAS p21 protein activator 2
External IDs	OMIM: 601589 MGI: 2149960 HomoloGene: 4745 GeneCards: RASA2
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	141,615,344 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	96,631,617 bp[2]
RNA expression pattern
	Top expressed in
	superficial temporal artery; ; cancellous bone; ; nipple; ; tibia; ; visceral pleura; ; Brodmann area 23; ; parietal pleura; ; Achilles tendon; ; cavity of mouth; ; germinal epithelium;
	Top expressed in
	secondary oocyte; ; median eminence; ; primary motor cortex; ; lymph node; ; olfactory bulb; ; renal corpuscle; ; mammillary body; ; conjunctival fornix; ; medullary collecting duct; ; arcuate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; GTPase activator activity; phospholipid binding;
Cellular component	cytoplasm; cytosol; intrinsic component of the cytoplasmic side of the plasma membrane; perinuclear region of cytoplasm;
Biological process	intracellular signal transduction; regulation of GTPase activity; MAPK cascade; positive regulation of GTPase activity; signal transduction; negative regulation of Ras protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	5922
	114713
	ENSG00000155903
	ENSMUSG00000032413
	Q15283
	P58069
	NM_001303245; NM_001303246; NM_006506
	NM_053268
	NP_001290174; NP_001290175; NP_006497
	NP_444498
	Wikidata
View/Edit Human	View/Edit Mouse

RAS p21 protein activator 2 is a protein that in humans is encoded by the RASA2 gene. [5]

Function

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].

References

GRCh38: Ensembl release 89: ENSG00000155903 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032413 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: RAS p21 protein activator 2". Retrieved 2018-09-14.

Ras p21 protein activator 2

Function

References

Further reading