Ribonucleoside-triphosphate reductase
Ribonucleoside-triphosphate reductase (EC 1.17.4.2, ribonucleotide reductase, 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase) is an enzyme with systematic name 2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction
- 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O ribonucleoside triphosphate + thioredoxin
| Ribonucleoside-triphosphate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Ribonucleoside-triphosphate reductase dimer, Thermotoga maritima | |||||||||
| Identifiers | |||||||||
| EC no. | 1.17.4.2 | ||||||||
| CAS no. | 9068-66-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Ribonucleoside-triphosphate reductase requires a cobamide coenzyme and ATP.
References
- Blakley RL (May 1965). "Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii". The Journal of Biological Chemistry. 240: 2173–80. PMID 14299643.
- Goulian M, Beck WS (September 1966). "Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii". The Journal of Biological Chemistry. 241 (18): 4233–42. PMID 5924645.
- Lammers, M.; Follmann, H. (1983). "The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation". Struct. Bonding. 54: 27–91. doi:10.1007/bfb0111318.
External links
- Ribonucleoside-triphosphate+reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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