Ring finger protein 19B

RNF19B
Identifiers
Aliases	RNF19B, IBRDC3, NKLAM, ring finger protein 19B
External IDs	OMIM: 610872 MGI: 1922484 HomoloGene: 34999 GeneCards: RNF19B
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	32,964,809 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	128,979,679 bp[2]
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; rectum; ; duodenum; ; appendix; ; smooth muscle tissue; ; gallbladder; ; skin of abdomen; ; jejunal mucosa; ; popliteal artery;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; saccule; ; otic placode; ; cerebellar cortex; ; cerebellar vermis; ; secondary oocyte; ; morula; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding; ubiquitin protein ligase activity; ubiquitin conjugating enzyme binding; ubiquitin-protein transferase activity; transferase activity; ubiquitin binding;
Cellular component	membrane; cytolytic granule; ubiquitin ligase complex; integral component of membrane; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; cytoplasm;
Biological process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process; adaptive immune response; immune system process; protein ubiquitination; protein polyubiquitination; ubiquitin-dependent protein catabolic process; protein autoubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	127544
	75234
	ENSG00000116514
	ENSMUSG00000028793
	Q6ZMZ0
	A2A7Q9
	NM_001127361; NM_001300826; NM_153341
	NM_029219; NM_001368763
	NP_001120833; NP_001287755; NP_699172
	NP_083495; NP_001355692
	Wikidata
View/Edit Human	View/Edit Mouse

Ring finger protein 19B is a protein that in humans is encoded by the RNF19B gene. [5]

Function

This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protein is an E3 ubiquitin-protein ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region.

References

GRCh38: Ensembl release 89: ENSG00000116514 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028793 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Ring finger protein 19B". Retrieved 2017-08-04.

Ring finger protein 19B

Function

References

Further reading