Roy Goodacre

Royston "Roy" Goodacre FRSC FLSW is Chair in Biological Chemistry at the University of Liverpool. With training in both Microbiology and Pyrolysis-Mass Spectrometry, Goodacre runs a multidisciplinary Metabolomics and Raman spectroscopy research group in the Institute of Systems, Molecular and Integrative Biology (ISMIB),[1] and leads ISMIB's Centre for Metabolomics Research and the Laboratory for Bioanalytical Spectroscopy.[2]

Roy Goodacre
Born
Changi, Singapore
Alma materBristol University (BSc, PhD)
Awards
  • FACSS Charles Mann Award (2021)
  • RSC Robert Boyle Prize (2021)
  • RSC Bioanalytical Chemistry Award (2005)
Scientific career
Fields
Institutions
ThesisThe Effects of Genotypic and Phenotypic Changes on Bacterial Identification using Pyrolysis Mass Spectrometry
Websitehttp://www.biospec.net

Early life and education

Goodacre was born in Changi, Singapore, and was educated from 1978 at the Monmouth School, in Wales, where he went on to study Biology, Chemistry and Mathematics at 'A' level. He received a 2i-class honours degree in Microbiology from the University of Bristol, where he was a student at Badock Hall Halls of residence at the University of Bristol, and remained to study for a PhD in pyrolysis-MS for bacterial identification[3] with the bacteriologist Dr Roger Berkeley at the University of Bristol,[4] defending his thesis in 1992. While in Bristol he met his wife: they married in 1991, celebrating 30 years of marriage in 2021, and have one daughter.

Roy Goodacre taking Raman measurements from pigments in Aboriginal Rock Art, Australia[5]

Career

Following his PhD, Goodacre took up a postdoctoral research position at Aberystwyth University between 1992 and 1995, and began his own research laboratory in 1995, with the award of a Wellcome Trust Research Career Development Fellowship, which he held until 1999, when he received tenure as a lecturer in Microbiology at Aberystwyth University. He moved to UMIST, which merged to become the University of Manchester, first as Reader in Analytical Science (Dept. of Chemistry, 2003–05) and then as Professor of Biological Chemistry, from 2005 to 2018. Goodacre was then recruited to the University of Liverpool to become Director of the Centre for Metabolomics Research (2018-).[6]

Goodacre is the founder and current Editor-in-Chief of the peer-reviewed scientific journal Metabolomics.[7] He is an Editorial Advisory Board member for the following journals: Analyst (2014-); Journal of Analytical and Applied Pyrolysis (1997-); Spectrochimica Acta A: Molecular and Biomolecular Spectroscopy (2016-).

Goodacre is a Founder and Director of the Metabolomics Society (2005–15, 2020–25) and currently its President.[8] Since 2008 he is also a Director of the Metabolic Profiling Forum.

He served as a Committee member of Royal Society of Chemistry's Analytical Division Council (2019-22).[9]

Since 2019 Goodacre has been a Trustee of the Analytical Chemistry Trust Fund (ACTF).[10]

Goodacre has supervised, and graduated, 53 PhD, 7 MSc and 2 MPhil postgraduate students.[11][12]

Awards and honours
  • The Nils Foss Excellence Prize 2021.[13]
  • FACSS Charles Mann Award for Applied Raman Spectroscopy (2021).[14]
  • RSC Analytical Division Horizon Prize: Robert Boyle Prize for Analytical Science (2021).[15]
  • The Analytical Scientist Power Lists in 2019,[16] 2020[17] and 2021.[18]
  • RSC Bioanalytical Chemistry Award (2005).[19]
  • Recipient of the Third Professor S. Ramaseshan Distinguished Lecture. AstraZeneca Research Foundation India, Bangalore, India (2004).

Research

Goodacre started Metabolomics research in the early 2000s with Douglas Kell.[20]  He helped to develop long-term metabolomics which allows fusion of GC-MS and LC-MS data collected over 12–24 months - which is based on mathematical corrections which effectively removes any (unavoidable) chromatographic and mass spectrometry instrumental drift.[21] This approach has been applied to generate profiles from ~1200 normal human serum samples[22] and to investigate human frailty in ageing populations of approx. 2000 individuals.[23]

Standardisation in Metabolomics is important and Goodacre was part of the Metabolomics Standards Initiative (MSI)[24][25] which help establish metabolite identification reporting standards,[26] which have been very well adopted by the field. He chaired part of the MSI's data analysis workgroup and these minimum reporting standards were published.[27]

Goodacre was the first to show that surface-enhanced Raman scattering can be used for bacterial identification[28] and to use Spatially Offset Raman spectroscopy for through-container authentication of spirit drinks.[29]

As of 2020, Goodacre has authored two international patents,[30][31] published over 400 peer-reviewed research articles and has an H-index of over 100 (see Google Scholar),[32] and edited two books on metabolomics.[33][34]

References
  1. "Roy Goodacre, Institute of Integrative Biology – University of Liverpool".
  2. "Laboratory for Bioanalytical Spectroscopy - Institute of Integrative Biology, University of Liverpool".
  3. PhD thesis (1992). The effects of genotypic and phenotypic changes on bacterial identification using pyrolysis mass spectrometry. bris.on.worldcat.org (PhD). Retrieved 29 March 2020.
  4. "Dr Roger Berkeley – University of Bristol".
  5. "Shining light on Aboriginal rock art".
  6. "News article: Professors appointed to strengthen University's expertise in metabolomics and systems biology". 12 September 2018.
  7. "Metabolomics, Springer Journals".
  8. "The Metabolomics Society".
  9. "Analytical Division Council".
  10. "Analytical Chemistry Trust Fund".
  11. "PhD awards".
  12. "MSc and MPhil awards".
  13. "The Nils Foss Excellence Prize 2021".
  14. "FACSS announces 2021 Charles Mann Award recipient".
  15. "RSC Analytical Division Horizon Prize: Robert Boyle Prize for Analytical Science (2021)".
  16. "Analytical Scientists Power List 2019".
  17. "Analytical Scientists Power List 2020".
  18. "Analytical Scientists Power List 2021".
  19. "RSC Bioanalytical Chemistry Award".
  20. Goodacre R, Vaidyanathan S, Dunn WB, Harrigan GG, Kell DB (2004). "Metabolomics by numbers: acquiring and understanding global metabolite data". Trends in Biotechnology. 2 (5): 245–252. doi:10.1016/j.tibtech.2004.03.007. PMID 15109811.
  21. Dunn WB, Broadhurst D, Begley P, Zelena E, McIntyre S, Anderson N, Brown M, Knowles JD, Halsall A, Haselden JN, Nicholls AW, Wilson ID, Kell DB, Goodacre R (2011). "Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry". Nature Protocols. 6 (7): 1060–1083. doi:10.1038/nprot.2011.335. PMID 21720319. S2CID 8152136.
  22. Dunn WB, Lin W, Broadhurst D, Begley P, Brown M, Zelena E, Vaughan AA, Halsall A, Harding N, Knowles JD, Francis-McIntyre S, Tseng A, Ellis DI, OHagan S, Aarons G, Benjamin B, Chew-Graham S, Moseley C, Potter P, Winder CL, Potts C, Thornton P, McWhirter C, Zubair M, Pan M, Burns A, Cruickshank JK, Jayson GC, Purandare N, Wu FC, Finn JD, Haselden JN, Nicholls AW, Wilson ID, Goodacre R, Kell DB (2015). "Molecular phenotyping of a UK population: defining the human serum metabolome". Metabolomics. 11 (1): 9–26. doi:10.1007/s11306-014-0707-1. PMC 4289517. PMID 25598764.
  23. Rattray NJ, Trivedi DK, Xu Y, Chandola T, Johnson CH, Marshall AD, Mekli K, Rattray Z, Tampubolon G, Vanhoutte B, White IR, Wu FC, Pendleton N, Nazroo J, Goodacre R (2019). "Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms identified as drivers behind human frailty". Nature Communications. 10 (1): 5027. doi:10.1038/s41467-019-12716-2. PMC 6831565. PMID 31690722.
  24. Sansone SA, Nikolau B, van Ommen B, Kristal BS, Taylor C, Robertson D, Lindon J, Griffin JL, Sumner LW, van der Werf M, Hardy NW, Morrison N, Mendes P, Kaddurah-Daouk R, Goodacre R, Fan T, Fiehn O (2007). "The Metabolomics Standards Initiative (MSI)". Nature Biotechnology. 25 (8): 846–849. doi:10.1038/nbt0807-846b. PMID 17687353. S2CID 20523053.
  25. Fiehn O, Robertson D, Griffin J, van der Werf M, Nikolau B, Morrison N, Sumner LW, Goodacre R, Hardy NW, Taylor C, Fostel J, Kristal B, Kaddurah-Daouk R, Mendes P, van Ommen B, Lindon JC, Sansone SA (2007). "The metabolomics standards initiative (MSI)". Metabolomics. 3 (3): 175–178. doi:10.1007/s11306-007-0070-6.
  26. Sumner LW, Amberg A, Barrett D, Beale MH, Beger R, Daykin CA, Fan TW, Fiehn O, Goodacre R, Griffin JL, Hankemeier T, Hardy N, Harnly J, Higashi R, Kopka J, Lane AN, Lindon JC, Marriott P, Nicholls AW, Reily MD, Thaden JJ, Viant MR (2007). "Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)". Metabolomics. 3 (3): 211–221. doi:10.1007/s11306-007-0082-2. PMC 3772505. PMID 24039616.
  27. Goodacre R, Broadhurst D, Smilde A, Kristal BS, Baker JD, Beger R, Bessant C, Connor S, Capuani G, Craig A, Ebbels T, Kell DB, Manetti C, Newton J, Paternostro G, Somorjai R, Sjöström M, Trygg J, Wulfert F (2007). "Proposed minimum reporting standards for data analysis in metabolomics". Metabolomics. 3 (3): 231–241. doi:10.1007/s11306-007-0081-3.
  28. Jarvis RM, Goodacre R (2004). "Rapid discrimination of bacteria using surface enhanced Raman spectroscopy". Analytical Chemistry. 76 (1): 40–47. doi:10.1021/ac034689c. PMID 14697030.
  29. Ellis DI, Eccles R, Xu Y, Griffen J, Muhamadali H, Matousek P, Goodall I, Goodacre R (2017). "Through-container, extremely low concentration detection of multiple chemical markers of counterfeit alcohol using a handheld SORS device". Scientific Reports. 7 (1): 12082. Bibcode:2017NatSR...712082E. doi:10.1038/s41598-017-12263-0. PMC 5608898. PMID 28935907.
  30. Goodacre R, Kell DB (1999), Composition analysis: WO9642058, US5946640
  31. Goodacre R, Upton M (2013), A method of analysing a sample including a microorganism of interest: PCTGB2015050551, EP3110963A1, WO2015128650A1, US20170073725A1
  32. "Roy Goodacre Google Scholar – University of Liverpool".
  33. Harrigan GG, Goodacre R (2003). "Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis". Kluwer Academic Publishers, Boston: 335. ISBN 978-1-4615-0333-0.
  34. Vaidyanathan S, Harrigan GG, Goodacre R (2005). Metabolome analyses: strategies for systems biology. Boston: Springer. p. 383. ISBN 978-0-387-25240-7.
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