23S rRNA (uracil747-C5)-methyltransferase

23S rRNA (uracil747-C5)-methyltransferase (EC 2.1.1.189, YbjF, RumB, RNA uridine methyltransferase B) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (uracil747-C5)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + uracil747 in 23S rRNA S-adenosyl-L-homocysteine + 5-methyluracil747 in 23S rRNA
23S rRNA (uracil747-C5)-methyltransferase
Identifiers
EC no.2.1.1.189
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme specifically methylates uracil747 at C5 in 23S rRNA.

References

  1. Madsen CT, Mengel-Jørgensen J, Kirpekar F, Douthwaite S (August 2003). "Identifying the methyltransferases for m(5)U747 and m(5)U1939 in 23S rRNA using MALDI mass spectrometry". Nucleic Acids Research. 31 (16): 4738–46. doi:10.1093/nar/gkg657. PMC 169892. PMID 12907714.
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