SAM-IV riboswitch
SAM-IV riboswitches are a kind of riboswitch that specifically binds S-adenosylmethionine (SAM),[1] a cofactor used in many methylation reactions. Originally identified by bioinformatics,[2] SAM-IV riboswitches are largely confined to the Actinomycetales, an order of Bacteria. Conserved features of SAM-IV riboswitch and experiments imply that they probably share a similar SAM-binding site to another class of SAM-binding riboswitches called SAM-I riboswitches. However, the scaffolds of these two types of riboswitch appear to be quite distinct. The structural relationship between these riboswitch types has been studied.[3][4]
| S-adenosyl methionine (SAM) riboswitch, | |
|---|---|
 Predicted secondary structure and sequence conservation of SAM-IV | |
| Identifiers | |
| Symbol | SAM-IV |
| Rfam | RF00634 CL00012 |
| Other data | |
| RNA type | Cis-reg; riboswitch |
| Domain(s) | Bacteria |
| SO | SO:0005836 |
| PDB structures | PDBe |
References
- Weinberg Z, Regulski EE, Hammond MC, et al. (2008). "The aptamer core of SAM-IV riboswitches mimics the ligand-binding site of SAM-I riboswitches". RNA. 14 (5): 822–828. doi:10.1261/rna.988608. PMC 2327355. PMID 18369181.
- Weinberg Z, Barrick JE, Yao Z, et al. (2007). "Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline". Nucleic Acids Res. 35 (14): 4809–4819. doi:10.1093/nar/gkm487. PMC 1950547. PMID 17621584.
- Trausch JJ, Xu Z, Edwards AL, Reyes FE, Ross PE, Knight R, Batey RT (May 2014). "Structural basis for diversity in the SAM clan of riboswitches". Proc Natl Acad Sci U S A. 111 (18): 6624–9. doi:10.1073/pnas.1312918111. PMC 4020084. PMID 24753586.
- Zhang K, Li S, Kappel K, Pintilie G, Su Z, Mou TC, Schmid MF, Das R, Chiu W (December 2019). "Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution". Nat Commun. 10 (1): 5511. doi:10.1038/s41467-019-13494-7. PMC 6890682. PMID 31796736.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.