SASH1

SASH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EBP
Identifiers
Aliases	SASH1, SH3D6A, dJ323M4, dJ323M4.1, SAM and SH3 domain containing 1, DUH1, CAPOK
External IDs	OMIM: 607955 MGI: 1917347 HomoloGene: 69182 GeneCards: SASH1
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	148,552,044 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	8,761,814 bp[2]
RNA expression pattern
	Top expressed in
	synovial joint; ; external globus pallidus; ; subthalamic nucleus; ; inferior ganglion of vagus nerve; ; cavity of mouth; ; Achilles tendon; ; superior vestibular nucleus; ; corpus callosum; ; ventral tegmental area; ; tibia;
	Top expressed in
	medial geniculate nucleus; ; lateral geniculate nucleus; ; substantia nigra; ; suprachiasmatic nucleus; ; ventral tegmental area; ; medial dorsal nucleus; ; lateral hypothalamus; ; body of femur; ; mammillary body; ; calvaria;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	mitogen-activated protein kinase kinase kinase binding; molecular adaptor activity; protein C-terminus binding; protein kinase binding;
Cellular component	protein-containing complex;
Biological process	positive regulation of endothelial cell migration; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of JUN kinase activity; regulation of protein K63-linked ubiquitination; positive regulation of p38MAPK cascade; regulation of protein autoubiquitination; protein polyubiquitination; positive regulation of NIK/NF-kappaB signaling; positive regulation of angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	23328
	70097
	ENSG00000111961
	ENSMUSG00000015305
	O94885
	P59808
NM_015278; NM_001346505; NM_001346506; NM_001346507; NM_001346508;
	NM_001346509
	NM_175155
NP_001333434; NP_001333435; NP_001333436; NP_001333437; NP_001333438;
	NP_056093
	NP_780364
	Wikidata
View/Edit Human	View/Edit Mouse

SAM and SH3 domain-containing protein 1 is a protein that in humans is encoded by the SASH1 gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000111961 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000015305 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Zeller C, Hinzmann B, Seitz S, Prokoph H, Burkhard-Goettges E, Fischer J, Jandrig B, Schwarz LE, Rosenthal A, Scherneck S (May 2003). "SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer". Oncogene. 22 (19): 2972–83. doi:10.1038/sj.onc.1206474. PMID 12771949.
"Entrez Gene: SASH1 SAM and SH3 domain containing 1".

Rimkus C, Martini M, Friederichs J, et al. (2007). "Prognostic significance of downregulated expression of the candidate tumour suppressor gene SASH1 in colon cancer". Br. J. Cancer. 95 (10): 1419–23. doi:10.1038/sj.bjc.6603452. PMC 2360597. PMID 17088907.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111961 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015305 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9872452-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

[pmid12771949-6] Zeller C, Hinzmann B, Seitz S, Prokoph H, Burkhard-Goettges E, Fischer J, Jandrig B, Schwarz LE, Rosenthal A, Scherneck S (May 2003). "SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer". Oncogene. 22 (19): 2972–83. doi:10.1038/sj.onc.1206474. PMID 12771949.

[entrez-7] "Entrez Gene: SASH1 SAM and SH3 domain containing 1".

SASH1

References

Further reading