SAT2

Diamine acetyltransferase 2 is an enzyme that in humans is encoded by the SAT2 gene.[5][6][7] SAT2 maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate.[8]

SAT2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSAT2, Sspermidine/spermine N1-acetyltransferase family member 2, SSAT-2
External IDsOMIM: 611463 MGI: 1916465 HomoloGene: 44215 GeneCards: SAT2
Orthologs
SpeciesHumanMouse
Entrez

112483

69215

Ensembl

ENSG00000141504

ENSMUSG00000069835

UniProt

Q96F10

Q6P8J2

RefSeq (mRNA)

NM_133491
NM_001320845
NM_001320846
NM_001320847

NM_026991
NM_001356468
NM_001356469

RefSeq (protein)

NP_001307774
NP_001307775
NP_001307776
NP_597998

NP_081267
NP_001343397
NP_001343398

Location (UCSC)Chr 17: 7.63 – 7.63 MbChr 11: 69.51 – 69.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000141504 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000069835 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Coleman CS, Stanley BA, Jones AD, Pegg AE (Nov 2004). "Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism". Biochem J. 384 (Pt 1): 139–48. doi:10.1042/BJ20040790. PMC 1134097. PMID 15283699.
  6. Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL (Aug 2007). "Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha". J Biol Chem. 282 (32): 23572–80. doi:10.1074/jbc.M703504200. PMID 17558023.
  7. "Entrez Gene: SAT2 spermidine/spermine N1-acetyltransferase 2".
  8. Jenstad M, Quazi AZ, Zilberter M, Haglerød C, Berghuis P, Saddique N, Goiny M, Buntup D, Davanger S, S Haug FM, Barnes CA, McNaughton BL, Ottersen OP, Storm-Mathisen J, Harkany T, Chaudhry FA (May 2009). "System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate". Cereb Cortex. 19 (5): 1092–106. doi:10.1093/cercor/bhn151. PMID 18832333.

Further reading


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