SDK1
Sidekick cell adhesion molecule 1 is a protein that in humans is encoded by the SDK1 gene. [5] [6]
| SDK1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | SDK1, sidekick cell adhesion molecule 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 607216 MGI: 2444413 HomoloGene: 27395 GeneCards: SDK1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
The protein encoded by this gene is a member of the immunoglobulin superfamily.[7] The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016].
References
- GRCh38: Ensembl release 89: ENSG00000146555 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000039683 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Sidekick cell adhesion molecule 1". Retrieved 2018-05-31.
- "OMIM: SIDEKICK CELL ADHESION MOLECULE 1; SDK1".
- Yamagata, M (2020). "Structure and Functions of Sidekicks". Frontiers in Molecular Neuroscience. 13: 139. doi:10.3389/fnmol.2020.00139. PMC 7479261. PMID 32982686.
Further reading
- Yamagata M (2020). "Structure and Functions of Sidekicks". Frontiers in Molecular Neuroscience. 13: 139. doi:10.3389/fnmol.2020.00139. PMC 7479261. PMID 32982686.
- Kaufman L, Hayashi K, Ross MJ, Ross MD, Klotman PE (July 2004). "Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy". J. Am. Soc. Nephrol. 15 (7): 1721–30. doi:10.1097/01.asn.0000128975.28958.c2. PMID 15213259.
- Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (January 2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
- Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (January 2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
- Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (April 2010). "Association of genetic variants with hemorrhagic stroke in Japanese individuals". Int. J. Mol. Med. 25 (4): 649–56. doi:10.3892/ijmm_00000388. PMID 20198315.
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
- Saus E, Brunet A, Armengol L, Alonso P, Crespo JM, Fernández-Aranda F, Guitart M, Martín-Santos R, Menchón JM, Navinés R, Soria V, Torrens M, Urretavizcaya M, Vallès V, Gratacòs M, Estivill X (October 2010). "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients". J Psychiatr Res. 44 (14): 971–8. doi:10.1016/j.jpsychires.2010.03.007. PMID 20398908.
- Kaufman L, Potla U, Coleman S, Dikiy S, Hata Y, Kurihara H, He JC, D'Agati VD, Klotman PE (August 2010). "Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis". J. Biol. Chem. 285 (33): 25677–85. doi:10.1074/jbc.M110.133959. PMC 2919131. PMID 20562105.
- Cadby G, Mukherjee S, Musk AW, Reid A, Garlepp M, Dick I, Robinson C, Hui J, Fiorito G, Guarrera S, Beilby J, Melton PE, Moses EK, Ugolini D, Mirabelli D, Bonassi S, Magnani C, Dianzani I, Matullo G, Robinson B, Creaney J, Palmer LJ (October 2013). "A genome-wide association study for malignant mesothelioma risk". Lung Cancer. 82 (1): 1–8. doi:10.1016/j.lungcan.2013.04.018. hdl:11567/604944. PMID 23827383.
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