SEC14L2

SEC14L2 is a gene that, in humans, encodes the protein SEC14-like protein 2.[5][6]

SEC14L2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSEC14L2, C22orf6, SPF, TAP, TAP1, SEC14 like lipid binding 2
External IDsOMIM: 607558 MGI: 1915065 HomoloGene: 8245 GeneCards: SEC14L2
Orthologs
SpeciesHumanMouse
Entrez

23541

67815

Ensembl

ENSG00000100003

ENSMUSG00000003585

UniProt

O76054

Q99J08

RefSeq (mRNA)

NM_033382
NM_001204204
NM_001291932
NM_012429

NM_144520

RefSeq (protein)

NP_001191133
NP_001278861
NP_036561
NP_203740
NP_036561.1

NP_653103

Location (UCSC)Chr 22: 30.4 – 30.43 MbChr 11: 4.05 – 4.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in metabolism of cholesterol.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000100003 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003585 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  6. "Entrez Gene: SEC14L2 SEC14-like 2 (S. cerevisiae)".

Further reading


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