SEC61G

Protein transport protein Sec61 subunit gamma is a protein that in humans is encoded by the SEC61G gene.[3][4][5]

SEC61G
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesSEC61G, SSS1, Sec61 translocon gamma subunit, SEC61 translocon subunit gamma
External IDsOMIM: 609215 HomoloGene: 40767 GeneCards: SEC61G
Orthologs
SpeciesHumanMouse
Entrez

23480

n/a

Ensembl

ENSG00000132432

n/a

UniProt

P60059

n/a

RefSeq (mRNA)

NM_014302
NM_001012456

n/a

RefSeq (protein)

NP_001012474
NP_055117

n/a

Location (UCSC)Chr 7: 54.75 – 54.76 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000132432 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Hartmann E, Sommer T, Prehn S, Görlich D, Jentsch S, Rapoport TA (February 1994). "Evolutionary conservation of components of the protein translocation complex". Nature. 367 (6464): 654–7. doi:10.1038/367654a0. PMID 8107851. S2CID 4323463.
  4. Greenfield JJ, High S (May 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". Journal of Cell Science. 112 ( Pt 10) (10): 1477–86. doi:10.1242/jcs.112.10.1477. PMID 10212142.
  5. "Entrez Gene: SEC61G Sec61 gamma subunit".

Further reading


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