SECISBP2

SECIS-binding protein 2 (commonly referred to as SBP2) is a protein that in humans is encoded by the SECISBP2 gene.[5][6]

SECISBP2
Identifiers
AliasesSECISBP2, SBP2, SECIS binding protein 2
External IDsOMIM: 607693 MGI: 1922670 HomoloGene: 11415 GeneCards: SECISBP2
Orthologs
SpeciesHumanMouse
Entrez

79048

75420

Ensembl

ENSG00000187742

ENSMUSG00000035139

UniProt

Q96T21

n/a

RefSeq (mRNA)

NM_029279
NM_001308448

RefSeq (protein)

n/a

Location (UCSC)Chr 9: 89.32 – 89.36 MbChr 13: 51.81 – 51.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. SBP2 is a nuclear protein that functions as a SECIS binding protein, but experimental evidence indicates that SBP2 is cytoplasmic.[6]

Clinical significance

Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000187742 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035139 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. "Entrez Gene: SECISBP2 SECIS binding protein 2".

Further reading


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