SEMG2

SEMG2
Identifiers
Aliases	SEMG2, SGII, semenogelin II, semenogelin 2
External IDs	OMIM: 182141 HomoloGene: 129832 GeneCards: SEMG2
Gene location (Human)
Chr.	Chromosome 20 (human)[1]
End	45,224,458 bp[1]
RNA expression pattern
	Top expressed in
	seminal vesicula; ; sperm; ; prostate; ; metanephros; ; kidney; ; human musculoskeletal system; ; muscular system; ; muscle; ; muscle; ; female reproductive system;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protease binding; protein binding; metal ion binding; zinc ion binding;
Cellular component	extracellular region; extracellular exosome; nucleus; extracellular space;
Biological process	antibacterial humoral response; positive regulation of serine-type endopeptidase activity; protein heterooligomerization; negative regulation of flagellated sperm motility; coagulation; sperm capacitation;
	Sources:Amigo / QuickGO
Orthologs
	6407
	n/a
	ENSG00000124157
	n/a
	Q02383
	n/a
	NM_003008
	n/a
	NP_002999
	n/a
	Wikidata
View/Edit Human

Semenogelin-2 is a protein that in humans is encoded by the SEMG2 gene.[3][4][5]

The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20.[5]

References

GRCh38: Ensembl release 89: ENSG00000124157 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ulvsback M, Lazure C, Lilja H, Spurr NK, Rao VV, Loffler C, Hansmann I, Lundwall A (Oct 1992). "Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20". J Biol Chem. 267 (25): 18080–4. doi:10.1016/S0021-9258(19)37155-8. PMID 1517240.
Peter A, Lilja H, Lundwall A, Malm J (Apr 1998). "Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase". Eur J Biochem. 252 (2): 216–21. doi:10.1046/j.1432-1327.1998.2520216.x. PMID 9523691.
"Entrez Gene: SEMG2 semenogelin II".

Lilja H, Lundwall A (1992). "Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein". Proc. Natl. Acad. Sci. U.S.A. 89 (10): 4559–63. Bibcode:1992PNAS...89.4559L. doi:10.1073/pnas.89.10.4559. PMC 49122. PMID 1584792.
Schneider K, Kausler W, Tripier D, et al. (1989). "[Isolation and structure determination of two peptides occurring in human seminal plasma]". Biol. Chem. Hoppe-Seyler. 370 (4): 353–6. doi:10.1515/bchm3.1989.370.1.353. PMID 2757795.
Lundwall A (1996). "The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA". Eur. J. Biochem. 235 (3): 466–70. doi:10.1111/j.1432-1033.1996.00466.x. PMID 8654389.
Malm J, Hellman J, Magnusson H, et al. (1996). "Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II". Eur. J. Biochem. 238 (1): 48–53. doi:10.1111/j.1432-1033.1996.0048q.x. PMID 8665951.
Kise H, Nishioka J, Kawamura J, Suzuki K (1996). "Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor". Eur. J. Biochem. 238 (1): 88–96. doi:10.1111/j.1432-1033.1996.0088q.x. PMID 8665956.
Bjartell A, Malm J, Moller C, et al. (1997). "Distribution and tissue expression of semenogelin I and II in man as demonstrated by in situ hybridization and immunocytochemistry". J. Androl. 17 (1): 17–26. PMID 8833737.
Ulvsbäck M, Lundwall A (1997). "Cloning of the semenogelin II gene of the rhesus monkey. Duplications of 360 bp extend the coding region in man, rhesus monkey and baboon". Eur. J. Biochem. 245 (1): 25–31. doi:10.1111/j.1432-1033.1997.00025.x. PMID 9128720.
Lövgren J, Airas K, Lilja H (1999). "Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors". Eur. J. Biochem. 262 (3): 781–9. doi:10.1046/j.1432-1327.1999.00433.x. PMID 10411640.
Malm J, Hellman J, Hogg P, Lilja H (2000). "Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor". Prostate. 45 (2): 132–9. doi:10.1002/1097-0045(20001001)45:2<132::AID-PROS7>3.0.CO;2-3. PMID 11027412. S2CID 35309283.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Brillard-Bourdet M, Réhault S, Juliano L, et al. (2002). "Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates". Eur. J. Biochem. 269 (1): 390–5. doi:10.1046/j.0014-2956.2001.02667.x. PMID 11784334.
Lundwall A, Bjartell A, Olsson AY, Malm J (2003). "Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues". Mol. Hum. Reprod. 8 (9): 805–10. doi:10.1093/molehr/8.9.805. PMID 12200457.
Ek P, Malm J, Lilja H, et al. (2003). "Exogenous protein kinases A and C, but not endogenous prostasome-associated protein kinase, phosphorylate semenogelins I and II from human semen". J. Androl. 23 (6): 806–14. PMID 12399526.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yoshida K, Yamasaki T, Yoshiike M, et al. (2004). "Quantification of seminal plasma motility inhibitor/semenogelin in human seminal plasma". J. Androl. 24 (6): 878–84. doi:10.1002/j.1939-4640.2003.tb03139.x. PMID 14581514.
Jensen-Seaman MI, Li WH (2004). "Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen". J. Mol. Evol. 57 (3): 261–70. CiteSeerX 10.1.1.328.9582. doi:10.1007/s00239-003-2474-x. PMID 14629036. S2CID 9728983.
Dorus S, Evans PD, Wyckoff GJ, et al. (2005). "Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity". Nat. Genet. 36 (12): 1326–9. doi:10.1038/ng1471. PMID 15531881. S2CID 9122060.
Jonsson M, Linse S, Frohm B, et al. (2005). "Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen". Biochem. J. 387 (Pt 2): 447–53. doi:10.1042/BJ20041424. PMC 1134973. PMID 15563730.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124157 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1517240-3] Ulvsback M, Lazure C, Lilja H, Spurr NK, Rao VV, Loffler C, Hansmann I, Lundwall A (Oct 1992). "Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20". J Biol Chem. 267 (25): 18080–4. doi:10.1016/S0021-9258(19)37155-8. PMID 1517240.

[pmid9523691-4] Peter A, Lilja H, Lundwall A, Malm J (Apr 1998). "Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase". Eur J Biochem. 252 (2): 216–21. doi:10.1046/j.1432-1327.1998.2520216.x. PMID 9523691.

[entrez-5] "Entrez Gene: SEMG2 semenogelin II".

SEMG2

See also

References

Further reading