SENP6

Sentrin-specific protease 6 is an enzyme that in humans is encoded by the SENP6 gene.[5]

SENP6
Identifiers
AliasesSENP6, SSP1, SUSP1, SUMO1/sentrin specific peptidase 6, SUMO specific peptidase 6
External IDsOMIM: 605003 MGI: 1922075 HomoloGene: 9196 GeneCards: SENP6
Orthologs
SpeciesHumanMouse
Entrez

26054

215351

Ensembl

ENSG00000112701

ENSMUSG00000034252

UniProt

Q9GZR1

Q6P7W0

RefSeq (mRNA)

NM_001100409
NM_001304792
NM_015571

NM_146003
NM_001311110

RefSeq (protein)

NP_001093879
NP_001291721
NP_056386

NP_001298039
NP_666115

Location (UCSC)Chr 6: 75.6 – 75.72 MbChr 9: 80.07 – 80.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Ubiquitin-like molecules (UBLs), such as SUMO1, are structurally related to ubiquitin and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000112701 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034252 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SENP6 SUMO1/sentrin specific peptidase 6".

Further reading

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