SEPP1
Selenoprotein P is a protein that in humans is encoded by the SEPP1 gene.[5][6]
| SELENOP | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | SELENOP, SELP, SeP, SEPP, SEPP1, selenoprotein P, plasma, 1, selenoprotein P | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 601484 MGI: 894288 HomoloGene: 3945 GeneCards: SELENOP | ||||||||||||||||||||||||||||||||||||||||||||||||||
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This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues (human, rat, mouse)[7] per polypeptide, one located at the C-terminal side of protein and others at the N-terminal side. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.[6]
Animal models
Mice and dogs with knock-out variants in their SEPP1 homologues (Selenop[8] and SELENOP[9] respectively) may develop cerebellar ataxia phenotypes.[10][11] SEPP1 and neural precursor cell levels in mouse brains increase post-exercise. Mice engineered to lack SEPP1 did not increase neural precursors.[12][13]
See also
References
- GRCh38: Ensembl release 89: ENSG00000250722 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000064373 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Hill KE, Lloyd RS, Burk RF (January 1993). "Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA". Proceedings of the National Academy of Sciences of the United States of America. 90 (2): 537–541. Bibcode:1993PNAS...90..537H. doi:10.1073/pnas.90.2.537. PMC 45698. PMID 8421687.
- "Entrez Gene: SEPP1 selenoprotein P, plasma, 1".
- Burk and Hill 2009
- "Selenop selenoprotein P [Mus musculus (house mouse)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-01-24.
- "SELENOP selenoprotein P [Canis lupus familiaris (dog)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-01-24.
- Christen M, Högler S, Kleiter M, Leschnik M, Weber C, Thaller D, et al. (August 2021). "Deletion of the SELENOP gene leads to CNS atrophy with cerebellar ataxia in dogs". PLOS Genetics. 17 (8): e1009716. doi:10.1371/journal.pgen.1009716. PMC 8360551. PMID 34339417.
- Schomburg L, Schweizer U, Holtmann B, Flohé L, Sendtner M, Köhrle J (March 2003). "Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues". The Biochemical Journal. 370 (Pt 2): 397–402. doi:10.1042/bj20021853. PMC 1223208. PMID 12521380.
- PÉREZ ORTEGA, RODRIGO (February 3, 2022). "Widely available supplement may explain brain boost from exercise". www.science.org. Retrieved 2022-02-07.
- Leiter, Odette; Zhuo, Zhan; Rust, Ruslan; Wasielewska, Joanna M.; Grönnert, Lisa; Kowal, Susann; Overall, Rupert W.; Adusumilli, Vijay S.; Blackmore, Daniel G.; Southon, Adam; Ganio, Katherine (3 February 2022). "Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging". Cell Metabolism. 34 (3): 408–423.e8. doi:10.1016/j.cmet.2022.01.005. PMID 35120590. S2CID 246556829.
Further reading
- Burk RF, Hill KE (October 1994). "Selenoprotein P. A selenium-rich extracellular glycoprotein". The Journal of Nutrition. 124 (10): 1891–1897. doi:10.1093/jn/124.10.1891. PMID 7931697.
- Mostert V (April 2000). "Selenoprotein P: properties, functions, and regulation". Archives of Biochemistry and Biophysics. 376 (2): 433–438. doi:10.1006/abbi.2000.1735. PMID 10775431.
- Hill KE, Lloyd RS, Yang JG, Read R, Burk RF (June 1991). "The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame". The Journal of Biological Chemistry. 266 (16): 10050–10053. doi:10.1016/S0021-9258(18)99185-4. PMID 2037562.
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Akesson B, Bellew T, Burk RF (February 1994). "Purification of selenoprotein P from human plasma". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1204 (2): 243–249. doi:10.1016/0167-4838(94)90014-0. PMID 8142465.
- Hill KE, Dasouki M, Phillips JA, Burk RF (September 1996). "Human selenoprotein P gene maps to 5q31". Genomics. 36 (3): 550–551. doi:10.1006/geno.1996.0505. PMID 8884283.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Mostert V, Lombeck I, Abel J (September 1998). "A novel method for the purification of selenoprotein P from human plasma". Archives of Biochemistry and Biophysics. 357 (2): 326–330. doi:10.1006/abbi.1998.0809. PMID 9735174.
- Saito Y, Hayashi T, Tanaka A, Watanabe Y, Suzuki M, Saito E, Takahashi K (January 1999). "Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase. Isolation and enzymatic characterization of human selenoprotein p". The Journal of Biological Chemistry. 274 (5): 2866–2871. doi:10.1074/jbc.274.5.2866. PMID 9915822.
- Koyama H, Omura K, Ejima A, Kasanuma Y, Watanabe C, Satoh H (February 1999). "Separation of selenium-containing proteins in human and mouse plasma using tandem high-performance liquid chromatography columns coupled with inductively coupled plasma-mass spectrometry". Analytical Biochemistry. 267 (1): 84–91. doi:10.1006/abio.1998.2949. PMID 9918658.
- Arteel GE, Franken S, Kappler J, Sies H (March 2000). "Binding of selenoprotein P to heparin: characterization with surface plasmon resonance". Biological Chemistry. 381 (3): 265–268. doi:10.1515/BC.2000.034. PMID 10782998. S2CID 36448244.
- Hondal RJ, Ma S, Caprioli RM, Hill KE, Burk RF (May 2001). "Heparin-binding histidine and lysine residues of rat selenoprotein P". The Journal of Biological Chemistry. 276 (19): 15823–15831. doi:10.1074/jbc.M010405200. PMID 11278668.
- Nishimura K, Matsumiya K, Tsujimura A, Koga M, Kitamura M, Okuyama A (2001). "Association of selenoprotein P with testosterone production in cultured Leydig cells". Archives of Andrology. 47 (1): 67–76. doi:10.1080/01485010152104026. PMID 11442337.
- Al-Taie OH, Seufert J, Mörk H, Treis H, Mentrup B, Thalheimer A, et al. (September 2002). "A complex DNA-repeat structure within the Selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency". European Journal of Human Genetics. 10 (9): 499–504. doi:10.1038/sj.ejhg.5200811. PMID 12173025.
- Saito Y, Takahashi K (November 2002). "Characterization of selenoprotein P as a selenium supply protein". European Journal of Biochemistry. 269 (22): 5746–5751. doi:10.1046/j.1432-1033.2002.03298.x. PMID 12423375.
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