KMT5A

N-lysine methyltransferase KMT5A is an enzyme that in humans is encoded by the KMT5A gene.[5][6][7][8] The enzyme is a histone methyltransferase, SET domain-containing and lysine-specific. The enzyme transfers one methyl group to histone H4 lysine residue at position 20. S-Adenosyl methionine (SAM) is both the cofactor and the methyl group donor. The lysine residue is converted to N6-methyllysine residue.

Leftmost: side chain of lysine. Next: N6-methyllysine side chain.
KMT5A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKMT5A, PR-Set7, SET07, SET8, SETD8, lysine methyltransferase 5A, PR/SET07
External IDsOMIM: 607240 MGI: 1915206 HomoloGene: 41372 GeneCards: KMT5A
EC number2.1.1.354
Orthologs
SpeciesHumanMouse
Entrez

387893

67956

Ensembl

ENSG00000183955

ENSMUSG00000049327

UniProt

Q9NQR1

Q2YDW7

RefSeq (mRNA)

NM_030241
NM_001310723
NM_001310725
NM_001310727

RefSeq (protein)
Location (UCSC)Chr 12: 123.38 – 123.41 MbChr 5: 124.58 – 124.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This histone modification is often abbreviated H4K20me1:

  • H4 - type of histone
  • K - symbol of lysine
  • 20 - position of the lysine residue modified
  • me - abbreviation for methyl group
  • 1 - number of methyl groups transferred

References

  1. GRCh38: Ensembl release 89: ENSG00000183955 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000049327 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Couture JF, Collazo E, Brunzelle JS, Trievel RC (June 2005). "Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase". Genes & Development. 19 (12): 1455–65. doi:10.1101/gad.1318405. PMC 1151662. PMID 15933070.
  6. Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, Reinberg D (June 2002). "PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin". Molecular Cell. 9 (6): 1201–13. doi:10.1016/S1097-2765(02)00548-8. PMID 12086618.
  7. Fang J, Feng Q, Ketel CS, Wang H, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Simon JA, Zhang Y (July 2002). "Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase". Current Biology. 12 (13): 1086–99. doi:10.1016/S0960-9822(02)00924-7. PMID 12121615. S2CID 15504308.
  8. "Entrez Gene: KMT5A lysine methyltransferase 5A [ Homo sapiens (human) ]".

Further reading


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