SFRP2

Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene.[5][6] This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.[6]

SFRP2
Identifiers
AliasesSFRP2, FRP-2, SARP1, SDF-5, secreted frizzled related protein 2
External IDsOMIM: 604157 MGI: 108078 HomoloGene: 56438 GeneCards: SFRP2
Orthologs
SpeciesHumanMouse
Entrez

6423

20319

Ensembl

ENSG00000145423

ENSMUSG00000027996

UniProt

Q96HF1

P97299

RefSeq (mRNA)

NM_003013

NM_009144

RefSeq (protein)

NP_003004

NP_033170

Location (UCSC)Chr 4: 153.78 – 153.79 MbChr 3: 83.67 – 83.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

New cardiomyocytes can be regenerated in the mouse heart via Sfrp2 and this may lead to treatment of heart injury .

Cancer

SFRP2 gene has been detected progressively overexpressed in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.[7] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000145423 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027996 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Melkonyan HS, Chang WC, Shapiro JP, Mahadevappa M, Fitzpatrick PA, Kiefer MC, Tomei LD, Umansky SR (Jan 1998). "SARPs: A family of secreted apoptosis-related proteins". Proc Natl Acad Sci U S A. 94 (25): 13636–41. doi:10.1073/pnas.94.25.13636. PMC 28358. PMID 9391078.
  6. "Entrez Gene: SFRP2 secreted frizzled-related protein 2".
  7. Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.

Further reading

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