TRA2B

Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (SFRS10), is a protein that in humans is encoded by the TRA2B gene.[5][6]

TRA2B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTRA2B, Htra2-beta, PPP1R156, SFRS10, SRFS10, TRA2-BETA, TRAN2B, transformer 2 beta homolog (Drosophila), transformer 2 beta homolog
External IDsOMIM: 602719 MGI: 106016 HomoloGene: 20965 GeneCards: TRA2B
Orthologs
SpeciesHumanMouse
Entrez

6434

20462

Ensembl

ENSG00000136527

ENSMUSG00000022858

UniProt

P62995

P62996

RefSeq (mRNA)

NM_001243879
NM_004593

NM_009186
NM_001330554
NM_001330555

RefSeq (protein)

NP_001230808
NP_004584

NP_001317483
NP_001317484
NP_033212

Location (UCSC)Chr 3: 185.91 – 185.94 MbChr 16: 22.06 – 22.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

TRA2B has been shown to interact with RBMX.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000136527 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022858 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SFRS10 splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)".
  6. Nayler O, Cap C, Stamm S (October 1998). "Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform". Genomics. 53 (2): 191–202. doi:10.1006/geno.1998.5471. PMID 9790768.
  7. Hofmann, Yvonne; Wirth Brunhilde (Aug 2002). "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1". Hum. Mol. Genet. 11 (17): 2037–49. doi:10.1093/hmg/11.17.2037. ISSN 0964-6906. PMID 12165565.

Further reading


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