SFRS11

SRSF11
Identifiers
Aliases	SRSF11, NET2, SFRS11, dJ677H15.2, p54, serine/arginine-rich splicing factor 11, serine and arginine rich splicing factor 11
External IDs	OMIM: 602010 MGI: 1916457 HomoloGene: 36164 GeneCards: SRSF11
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	70,253,052 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	158,036,639 bp[2]
RNA expression pattern
	Top expressed in
	visceral pleura; ; parietal pleura; ; tibia; ; gastric mucosa; ; Achilles tendon; ; endothelial cell; ; sural nerve; ; germinal epithelium; ; Brodmann area 23; ; right uterine tube;
	Top expressed in
	abdominal wall; ; cerebellar cortex; ; saccule; ; primitive streak; ; dermis; ; vas deferens; ; superior frontal gyrus; ; thymus; ; otic placode; ; maxillary prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; RNA binding;
Cellular component	nucleus; nucleoplasm; nuclear speck;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA processing; mRNA 3'-end processing; mRNA export from nucleus; RNA splicing; RNA export from nucleus;
	Sources:Amigo / QuickGO
Orthologs
	9295
	69207
	ENSG00000116754
	ENSMUSG00000055436
	Q05519; Q5T757
	n/a
NM_001190987; NM_004768; NM_001350605; NM_001350606; NM_001350607;
	NM_001350608; NM_001350609; NM_001350610; NM_001350611; NM_001350612; NM_001350613; NM_001350614; NM_001350615; NM_001350616; NM_001394402; NM_001394403; NM_001394404; NM_001394405; NM_001394406; NM_001394407; NM_001394408
	NM_001093752; NM_001093753; NM_026989; NM_001356997
NP_001177916; NP_004759; NP_001337534; NP_001337535; NP_001337536;
	NP_001337537; NP_001337538; NP_001337539; NP_001337540; NP_001337541; NP_001337542; NP_001337543; NP_001337544; NP_001337545
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.[5][6]

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing.[6]

Interactions

SFRS11 has been shown to interact with U2AF2.[7]

References

GRCh38: Ensembl release 89: ENSG00000116754 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000055436 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Chaudhary N; McMahon C; Blobel G (October 1991). "Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components". Proc Natl Acad Sci U S A. 88 (18): 8189–93. Bibcode:1991PNAS...88.8189C. doi:10.1073/pnas.88.18.8189. PMC 52472. PMID 1896467.
"Entrez Gene: SFRS11 splicing factor, arginine/serine-rich 11".
Zhang, W J; Wu J Y (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. UNITED STATES. 16 (10): 5400–8. doi:10.1128/MCB.16.10.5400. ISSN 0270-7306. PMC 231539. PMID 8816452.

Zhang WJ; Wu JY (1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. 16 (10): 5400–8. doi:10.1128/MCB.16.10.5400. PMC 231539. PMID 8816452.
Straub T, Grue P, Uhse A, et al. (1998). "The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction". J. Biol. Chem. 273 (41): 26261–4. doi:10.1074/jbc.273.41.26261. PMID 9756848.
Page-McCaw PS; Amonlirdviman K; Sharp PA (2000). "PUF60: a novel U2AF65-related splicing activity". RNA. 5 (12): 1548–60. doi:10.1017/S1355838299991938. PMC 1369877. PMID 10606266.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo". Mol. Cell. Biol. 24 (3): 1174–87. doi:10.1128/MCB.24.3.1174-1187.2004. PMC 321435. PMID 14729963.
Wu JY, Kar A, Kuo D, et al. (2006). "SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy". Mol. Cell. Biol. 26 (18): 6739–47. doi:10.1128/MCB.00739-06. PMC 1592875. PMID 16943417.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116754 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055436 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1896467-5] Chaudhary N; McMahon C; Blobel G (October 1991). "Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components". Proc Natl Acad Sci U S A. 88 (18): 8189–93. Bibcode:1991PNAS...88.8189C. doi:10.1073/pnas.88.18.8189. PMC 52472. PMID 1896467.

[entrez-6] "Entrez Gene: SFRS11 splicing factor, arginine/serine-rich 11".

[pmid8816452-7] Zhang, W J; Wu J Y (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. UNITED STATES. 16 (10): 5400–8. doi:10.1128/MCB.16.10.5400. ISSN 0270-7306. PMC 231539. PMID 8816452.

SFRS11

Interactions

References

Further reading