SFRS11

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.[5][6]

SRSF11
Identifiers
AliasesSRSF11, NET2, SFRS11, dJ677H15.2, p54, serine/arginine-rich splicing factor 11, serine and arginine rich splicing factor 11
External IDsOMIM: 602010 MGI: 1916457 HomoloGene: 36164 GeneCards: SRSF11
Orthologs
SpeciesHumanMouse
Entrez

9295

69207

Ensembl

ENSG00000116754

ENSMUSG00000055436

UniProt

Q05519
Q5T757

n/a

RefSeq (mRNA)

NM_001093752
NM_001093753
NM_026989
NM_001356997

RefSeq (protein)

n/a

Location (UCSC)Chr 1: 70.21 – 70.25 MbChr 3: 158.01 – 158.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing.[6]

Interactions

SFRS11 has been shown to interact with U2AF2.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000116754 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000055436 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chaudhary N; McMahon C; Blobel G (October 1991). "Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components". Proc Natl Acad Sci U S A. 88 (18): 8189–93. Bibcode:1991PNAS...88.8189C. doi:10.1073/pnas.88.18.8189. PMC 52472. PMID 1896467.
  6. "Entrez Gene: SFRS11 splicing factor, arginine/serine-rich 11".
  7. Zhang, W J; Wu J Y (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. UNITED STATES. 16 (10): 5400–8. doi:10.1128/MCB.16.10.5400. ISSN 0270-7306. PMC 231539. PMID 8816452.

Further reading


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