SGPL1

Sphingosine-1-phosphate lyase 1 is an enzyme that in humans is encoded by the SGPL1 gene.[5][6][7]

SGPL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSGPL1, S1PL, SPL, sphingosine-1-phosphate lyase 1, NPHS14
External IDsOMIM: 603729 MGI: 1261415 HomoloGene: 2897 GeneCards: SGPL1
Orthologs
SpeciesHumanMouse
Entrez

8879

20397

Ensembl

ENSG00000166224

ENSMUSG00000020097

UniProt

O95470

Q8R0X7

RefSeq (mRNA)

NM_003901

NM_009163
NM_001316673
NM_001316674

RefSeq (protein)

NP_003892

NP_001303602
NP_001303603
NP_033189

Location (UCSC)Chr 10: 70.82 – 70.88 MbChr 10: 60.93 – 60.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


References

  1. GRCh38: Ensembl release 89: ENSG00000166224 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020097 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhou J, Saba JD (Mar 1998). "Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast". Biochem Biophys Res Commun. 242 (3): 502–7. doi:10.1006/bbrc.1997.7993. PMID 9464245.
  6. Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD (Nov 2006). "Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer". Proc Natl Acad Sci U S A. 103 (46): 17384–9. Bibcode:2006PNAS..10317384O. doi:10.1073/pnas.0600050103. PMC 1859938. PMID 17090686.
  7. "Entrez Gene: SGPL1 sphingosine-1-phosphate lyase 1".

Further reading


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