SGTA

Small glutamine-rich tetratricopeptide repeat-containing protein alpha is a protein that in humans is encoded by the SGTA gene.[5][6][7] SGTA orthologs[8] have also been identified in several mammals for which complete genome data are available.

SGTA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSGTA, SGT, alphaSGT, hSGT, small glutamine rich tetratricopeptide repeat containing alpha, small glutamine rich tetratricopeptide repeat co-chaperone alpha, SGT1, Vpu
External IDsOMIM: 603419 MGI: 1098703 HomoloGene: 31122 GeneCards: SGTA
Orthologs
SpeciesHumanMouse
Entrez

6449

52551

Ensembl

ENSG00000104969

ENSMUSG00000004937

UniProt

O43765

Q8BJU0

RefSeq (mRNA)

NM_003021

NM_024499
NM_001358549
NM_001358550

RefSeq (protein)

NP_003012

NP_078775
NP_001345478
NP_001345479

Location (UCSC)Chr 19: 2.75 – 2.78 MbChr 10: 80.88 – 80.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.[7]

Interactions

SGTA has been shown to interact with Growth hormone receptor.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000104969 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000004937 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kordes E, Savelyeva L, Schwab M, Rommelaere J, Jauniaux JC, Cziepluch C (Aug 1998). "Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans". Genomics. 52 (1): 90–94. doi:10.1006/geno.1998.5385. PMID 9740675.
  6. Schantl JA, Roza M, De Jong AP, Strous GJ (Aug 2003). "Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor". The Biochemical Journal. 373 (Pt 3): 855–863. doi:10.1042/BJ20021591. PMC 1223544. PMID 12735788.
  7. "Entrez Gene: SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha".
  8. "OrthoMaM phylogenetic marker: SGTA coding sequence". Archived from the original on 2016-03-03. Retrieved 2010-02-17.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.