SH3BP5

SH3BP5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4H3B
Identifiers
Aliases	SH3BP5, SAB, SH3BP-5, SH3 domain binding protein 5
External IDs	OMIM: 605612 MGI: 1344391 HomoloGene: 23450 GeneCards: SH3BP5
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	15,341,368 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	31,158,035 bp[2]
RNA expression pattern
	Top expressed in
	endothelial cell; ; germinal epithelium; ; trigeminal ganglion; ; pericardium; ; visceral pleura; ; secondary oocyte; ; adrenal cortex; ; spinal ganglia; ; sural nerve; ; cerebellar vermis;
	Top expressed in
	barrel cortex; ; sexually immature organism; ; endocardial cushion; ; atrioventricular valve; ; saccule; ; renal corpuscle; ; cerebellar vermis; ; ureter; ; spleen; ; ankle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase inhibitor activity; protein binding; SH3 domain binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; mitochondrion; nucleoplasm; nuclear body; cytoplasmic vesicle membrane; membrane; cytoplasmic vesicle;
Biological process	signal transduction; negative regulation of protein tyrosine kinase activity; intracellular signal transduction; negative regulation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	9467
	24056
	ENSG00000131370
	ENSMUSG00000021892
	O60239
	Q9Z131
	NM_001018009; NM_004844
	NM_011894; NM_001347585
	NP_001018009; NP_004835
NP_001334514; NP_036024; NP_001391515; NP_001391516; NP_001391517;
	NP_001391518
	Wikidata
View/Edit Human	View/Edit Mouse

SH3 domain-binding protein 5 is a protein that in humans is encoded by the SH3BP5 gene.[5][6][7]

Interactions

SH3BP5 has been shown to interact with Bruton's tyrosine kinase[5][6] and MAPK8.[8]

References

GRCh38: Ensembl release 89: ENSG00000131370 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021892 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Matsushita M, Yamadori T, Kato S, Takemoto Y, Inazawa J, Baba Y, et al. (April 1998). "Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK)". Biochemical and Biophysical Research Communications. 245 (2): 337–343. doi:10.1006/bbrc.1998.8420. PMID 9571151.
Yamadori T, Baba Y, Matsushita M, Hashimoto S, Kurosaki M, Kurosaki T, et al. (May 1999). "Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein". Proceedings of the National Academy of Sciences of the United States of America. 96 (11): 6341–6346. Bibcode:1999PNAS...96.6341Y. doi:10.1073/pnas.96.11.6341. PMC 26883. PMID 10339589.
"Entrez Gene: SH3BP5 SH3-domain binding protein 5 (BTK-associated)".
Wiltshire C, Matsushita M, Tsukada S, Gillespie DA, May GH (November 2002). "A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria". The Biochemical Journal. 367 (Pt 3): 577–585. doi:10.1042/BJ20020553. PMC 1222945. PMID 12167088.

Further reading a

Win S, Than TA, Han D, Petrovic LM, Kaplowitz N (October 2011). "c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice". The Journal of Biological Chemistry. 286 (40): 35071–35078. doi:10.1074/jbc.M111.276089. PMC 3186406. PMID 21844199.
Win S, Than TA, Le BH, García-Ruiz C, Fernandez-Checa JC, Kaplowitz N (June 2015). "Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity". Journal of Hepatology. 62 (6): 1367–1374. doi:10.1016/j.jhep.2015.01.032. PMC 4439305. PMID 25666017.
Win S, Min RW, Zhang J, Kanel G, Wanken B, Chen Y, et al. (December 2021). "Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis". Hepatology. 74 (6): 3127–3145. doi:10.1002/hep.32083. PMC 8639630. PMID 34331779.
Baba Y, Matsushita M, Matsuda Y, Inazawa J, Yamadori T, Hashimoto S, et al. (2000). "Assignment of SH3BP5/Sh3bp5 encoding sab, an SH3 domain-binding protein which preferentially associates with Bruton's tyrosine kinase, to human chromosome 1q43 and mouse chromosome 14B by in situ hybridization". Cytogenetics and Cell Genetics. 87 (3–4): 221–222. doi:10.1159/000015430. PMID 10702676. S2CID 41425074.
Wiltshire C, Matsushita M, Tsukada S, Gillespie DA, May GH (November 2002). "A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria". The Biochemical Journal. 367 (Pt 3): 577–585. doi:10.1042/BJ20020553. PMC 1222945. PMID 12167088.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Court NW, Kuo I, Quigley O, Bogoyevitch MA (June 2004). "Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3". Biochemical and Biophysical Research Communications. 319 (1): 130–137. doi:10.1016/j.bbrc.2004.04.148. PMID 15158451.
Wiltshire C, Gillespie DA, May GH (December 2004). "Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein". Biochemical Society Transactions. 32 (Pt 6): 1075–1077. doi:10.1042/BST0321075. PMID 15506969.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131370 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021892 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9571151-5] Matsushita M, Yamadori T, Kato S, Takemoto Y, Inazawa J, Baba Y, et al. (April 1998). "Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK)". Biochemical and Biophysical Research Communications. 245 (2): 337–343. doi:10.1006/bbrc.1998.8420. PMID 9571151.

[pmid10339589-6] Yamadori T, Baba Y, Matsushita M, Hashimoto S, Kurosaki M, Kurosaki T, et al. (May 1999). "Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein". Proceedings of the National Academy of Sciences of the United States of America. 96 (11): 6341–6346. Bibcode:1999PNAS...96.6341Y. doi:10.1073/pnas.96.11.6341. PMC 26883. PMID 10339589.

[entrez-7] "Entrez Gene: SH3BP5 SH3-domain binding protein 5 (BTK-associated)".

[pmid12167088-8] Wiltshire C, Matsushita M, Tsukada S, Gillespie DA, May GH (November 2002). "A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria". The Biochemical Journal. 367 (Pt 3): 577–585. doi:10.1042/BJ20020553. PMC 1222945. PMID 12167088.