SHC2

SHC-transforming protein 2 is a protein that in humans is encoded by the SHC2 gene.[5][6][7]

SHC2
Identifiers
AliasesSHC2, SCK, SHCB, SLI, SHC adaptor protein 2
External IDsOMIM: 605217 MGI: 106180 HomoloGene: 19127 GeneCards: SHC2
Orthologs
SpeciesHumanMouse
Entrez

25759

216148

Ensembl

ENSG00000129946

ENSMUSG00000020312

UniProt

P98077

Q8BMC3

RefSeq (mRNA)

NM_012435
NM_001387056

NM_001024539

RefSeq (protein)

NP_036567

NP_001019710

Location (UCSC)Chr 19: 0.42 – 0.46 MbChr 10: 79.45 – 79.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

SHC2 has been shown to interact with Kinase insert domain receptor.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000129946 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020312 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kavanaugh WM; Williams LT (Jan 1995). "An alternative to SH2 domains for binding tyrosine-phosphorylated proteins". Science. 266 (5192): 1862–5. Bibcode:1994Sci...266.1862K. doi:10.1126/science.7527937. PMID 7527937.
  6. Nakamura T; Muraoka S; Sanokawa R; Mori N (Apr 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J Biol Chem. 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. PMID 9507002.
  7. "Entrez Gene: SHC2 SHC (Src homology 2 domain containing) transforming protein 2".
  8. Warner, A J; Lopez-Dee J; Knight E L; Feramisco J R; Prigent S A (Apr 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. England. 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. ISSN 0264-6021. PMC 1220983. PMID 10749680.

Further reading


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