SHPRH

E3 ubiquitin-protein ligase SHPRH is an enzyme that in humans is encoded by the SHPRH gene.[5][6]

SHPRH
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSHPRH, bA545I5.2, SNF2 histone linker PHD RING helicase, RAD5
External IDsOMIM: 608048 MGI: 1917581 HomoloGene: 6489 GeneCards: SHPRH
Orthologs
SpeciesHumanMouse
Entrez

257218

268281

Ensembl

ENSG00000146414

ENSMUSG00000090112

UniProt

Q149N8

Q7TPQ3

RefSeq (mRNA)

NM_001042683
NM_173082
NM_001370327
NM_001370328

NM_001077707
NM_001284354
NM_172937

RefSeq (protein)

NP_001036148
NP_775105
NP_001357256
NP_001357257

NP_001071175
NP_001271283
NP_766525

Location (UCSC)Chr 6: 145.86 – 145.96 MbChr 10: 11.03 – 11.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases.[supplied by OMIM][6] SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000146414 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000090112 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sood R, Makalowska I, Galdzicki M, Hu P, Eddings E, Robbins CM, Moses T, Namkoong J, Chen S, Trent JM (August 2003). "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region". Genomics. 82 (2): 153–61. doi:10.1016/S0888-7543(03)00121-6. PMID 12837266.
  6. "Entrez Gene: SHPRH SNF2 histone linker PHD RING helicase".
  7. Brühl, J; Trautwein, J; Schäfer, A; Linne, U; Bouazoune, K (21 August 2019). "The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase". Epigenetics & Chromatin. 12 (1): 52. doi:10.1186/s13072-019-0294-5. PMC 6702750. PMID 31434570.

Further reading

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