SKAP2

Src kinase-associated phosphoprotein 2 is an enzyme that in humans is encoded by the SKAP2 gene.[5][6][7]

SKAP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSKAP2, PRAP, RA70, SAPS, SCAP2, SKAP-HOM, SKAP55R, src kinase associated phosphoprotein 2
External IDsOMIM: 605215 MGI: 1889206 HomoloGene: 2919 GeneCards: SKAP2
Orthologs
SpeciesHumanMouse
Entrez

8935

54353

Ensembl

ENSG00000005020

ENSMUSG00000059182

UniProt

O75563

Q3UND0

RefSeq (mRNA)

NM_003930
NM_001303468

NM_018773

RefSeq (protein)

NP_001290397
NP_003921

NP_061243

Location (UCSC)Chr 7: 26.67 – 27 MbChr 6: 51.83 – 51.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells, but particularly specific in macrophages. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation.[7] It interacts with Signal-regulatory protein alpha and directs integrin-activated cytoskeletal reorganization in macrophages.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000005020 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000059182 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kouroku Y, Soyama A, Fujita E, Urase K, Tsukahara T, Momoi T (November 1998). "RA70 is a src kinase-associated protein expressed ubiquitously". Biochemical and Biophysical Research Communications. 252 (3): 738–42. doi:10.1006/bbrc.1998.9637. PMID 9837776.
  6. Marie-Cardine A, Verhagen AM, Eckerskorn C, Schraven B (September 1998). "SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55". FEBS Letters. 435 (1): 55–60. doi:10.1016/S0014-5793(98)01040-0. PMID 9755858. S2CID 37288744.
  7. "Entrez Gene: SKAP2 src kinase associated phosphoprotein 2".
  8. Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD (November 2012). "Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement". Journal of Cell Science. 125 (Pt 22): 5535–45. doi:10.1242/jcs.111260. PMC 3561861. PMID 22976304.

Further reading

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