SLA2

Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.[5][6]

SLA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSLA2, C20orf156, MARS, SLAP-2, SLAP2, Src-like-adaptor 2, Src like adaptor 2
External IDsOMIM: 606577 MGI: 1925049 HomoloGene: 49989 GeneCards: SLA2
Orthologs
SpeciesHumanMouse
Entrez

84174

77799

Ensembl

ENSG00000101082

ENSMUSG00000027636

UniProt

Q9H6Q3

Q8R4L0

RefSeq (mRNA)

NM_032214
NM_175077

NM_029983
NM_001356495

RefSeq (protein)

NP_115590
NP_778252

NP_084259
NP_001343424

Location (UCSC)Chr 20: 36.61 – 36.65 MbChr 2: 156.71 – 156.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.[6]

Interactions

SLA2 has been shown to interact with Cbl gene.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000101082 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027636 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A, Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS, Wu J (Nov 2001). "Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling". J Exp Med. 194 (9): 1263–76. CiteSeerX 10.1.1.283.1429. doi:10.1084/jem.194.9.1263. PMC 2195979. PMID 11696592.
  6. "Entrez Gene: SLA2 Src-like-adaptor 2".
  7. Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M (May 2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling". J. Biol. Chem. 277 (21): 19131–8. doi:10.1074/jbc.M110318200. PMID 11891219.

Further reading


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