SLAMF6

SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.[5][6]

SLAMF6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSLAMF6, CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000, SLAM family member 6
External IDsOMIM: 606446 MGI: 1353620 HomoloGene: 49945 GeneCards: SLAMF6
Orthologs
SpeciesHumanMouse
Entrez

114836

30925

Ensembl

ENSG00000162739

ENSMUSG00000015314

UniProt

Q96DU3

Q9ET39

RefSeq (mRNA)

NM_052931
NM_001184714
NM_001184715
NM_001184716

NM_030710
NM_001347186
NM_001347187

RefSeq (protein)

NP_001171643
NP_001171644
NP_001171645
NP_443163

NP_001334115
NP_001334116
NP_109635

Location (UCSC)Chr 1: 160.49 – 160.52 MbChr 1: 171.75 – 171.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000162739 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000015314 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bottino C, Falco M, Parolini S, Marcenaro E, Augugliaro R, Sivori S, Landi E, Biassoni R, Notarangelo LD, Moretta L, Moretta A (Aug 2001). "NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease". J Exp Med. 194 (3): 235–46. doi:10.1084/jem.194.3.235. PMC 2193462. PMID 11489943.
  6. "Entrez Gene: SLAMF6 SLAM family member 6".

Further reading

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