SLC9B2

Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 is a protein that in humans is encoded by the SLC9B2 gene.[5]

SLC9B2
Identifiers
AliasesSLC9B2, NHA2, NHE10, NHEDC2, solute carrier family 9 member B2
External IDsOMIM: 611789 MGI: 2140077 HomoloGene: 45381 GeneCards: SLC9B2
Orthologs
SpeciesHumanMouse
Entrez

133308

97086

Ensembl

ENSG00000164038

ENSMUSG00000037994

UniProt

Q86UD5

Q5BKR2

RefSeq (mRNA)

NM_001300754
NM_001300756
NM_178833

NM_178877

RefSeq (protein)

NP_849208

Location (UCSC)Chr 4: 103.02 – 103.09 MbChr 3: 135.01 – 135.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Sodium–hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000164038 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037994 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2".
  6. Xiang M, Feng M, Muend S, Rao R (November 2007). "A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension". Proceedings of the National Academy of Sciences of the United States of America. 104 (47): 18677–81. Bibcode:2007PNAS..10418677X. doi:10.1073/pnas.0707120104. PMC 2141836. PMID 18000046.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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