SLITRK2

SLIT and NTRK-like protein 2 is a protein that in humans is encoded by the SLITRK2 gene.[5][6][7]

SLITRK2
Identifiers
AliasesSLITRK2, CXorf2, SLITL1, SLIT and NTRK like family member 2, CXorf1, TMEM257
External IDsOMIM: 300561 MGI: 2679449 HomoloGene: 13054 GeneCards: SLITRK2
Orthologs
SpeciesHumanMouse
Entrez

84631

245450

Ensembl

ENSG00000185985

ENSMUSG00000036790

UniProt

Q9H156

Q810C0

RefSeq (mRNA)

NM_001161431
NM_198863

RefSeq (protein)

NP_001154903
NP_942563

Location (UCSC)Chr X: 145.82 – 145.83 MbChr X: 65.69 – 65.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Members of the SLITRK family, such as SLITRK2, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK2, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity.[7][6]

References
  1. GRCh38: Ensembl release 89: ENSG00000185985 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000036790 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (April 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
  6. Aruga J, Yokota N, Mikoshiba K (October 2003). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene. 315: 87–94. doi:10.1016/S0378-1119(03)00715-7. PMID 14557068.
  7. "Entrez Gene: SLITRK2 SLIT and NTRK-like family, member 2".

Further reading


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