SMARCA5

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 is a protein that in humans is encoded by the SMARCA5 gene.[5][6]

SMARCA5
Identifiers
AliasesSMARCA5, ISWI, SNF2H, WCRF135, hISWI, hSNF2H, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
External IDsOMIM: 603375 MGI: 1935129 HomoloGene: 55764 GeneCards: SMARCA5
Orthologs
SpeciesHumanMouse
Entrez

8467

93762

Ensembl

ENSG00000153147

ENSMUSG00000031715

UniProt

O60264

Q91ZW3

RefSeq (mRNA)

NM_003601

NM_053124

RefSeq (protein)

NP_003592

NP_444354

Location (UCSC)Chr 4: 143.51 – 143.56 MbChr 8: 81.43 – 81.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the ISWI family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.[6]

Interactions

SMARCA5 has been shown to interact with RAD21,[7] Histone deacetylase 2,[7] POLE3,[8] SATB1[9] and BAZ1A.[7][8][9][10][11]

References

  1. GRCh38: Ensembl release 89: ENSG00000153147 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031715 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Aihara T, Miyoshi Y, Koyama K, Suzuki M, Takahashi E, Monden M, Nakamura Y (October 1998). "Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI". Cytogenetics and Cell Genetics. 81 (3–4): 191–3. doi:10.1159/000015027. PMID 9730600. S2CID 46768416.
  6. "Entrez Gene: SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5".
  7. Hakimi MA, Bochar DA, Schmiesing JA, Dong Y, Barak OG, Speicher DW, Yokomori K, Shiekhattar R (Aug 2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature. 418 (6901): 994–8. Bibcode:2002Natur.418..994H. doi:10.1038/nature01024. PMID 12198550. S2CID 4344470.
  8. Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Jul 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". The EMBO Journal. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.
  9. Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature. 419 (6907): 641–5. Bibcode:2002Natur.419..641Y. doi:10.1038/nature01084. PMID 12374985. S2CID 25822700.
  10. Bochar DA, Savard J, Wang W, Lafleur DW, Moore P, Côté J, Shiekhattar R (Feb 2000). "A family of chromatin remodeling factors related to Williams syndrome transcription factor". Proceedings of the National Academy of Sciences of the United States of America. 97 (3): 1038–43. Bibcode:2000PNAS...97.1038B. doi:10.1073/pnas.97.3.1038. PMC 15513. PMID 10655480.
  11. Bozhenok L, Wade PA, Varga-Weisz P (May 2002). "WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci". The EMBO Journal. 21 (9): 2231–41. doi:10.1093/emboj/21.9.2231. PMC 125993. PMID 11980720.

Further reading


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