SMARCD2

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 is a protein that in humans is encoded by the SMARCD2 gene.[5][6][7]

SMARCD2
Identifiers
AliasesSMARCD2, BAF60B, CRACD2, Rsc6p, PRO2451, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2, SGD2
External IDsOMIM: 601736 MGI: 1933621 HomoloGene: 20671 GeneCards: SMARCD2
Orthologs
SpeciesHumanMouse
Entrez

6603

83796

Ensembl

ENSG00000108604

ENSMUSG00000078619

UniProt

Q92925

Q99JR8

RefSeq (mRNA)

NM_001098426
NM_003077
NM_001330439
NM_001330440

NM_001130187
NM_031878

RefSeq (protein)

NP_001091896
NP_001317368
NP_001317369

NP_001123659
NP_114084

Location (UCSC)Chr 17: 63.83 – 63.84 MbChr 11: 106.15 – 106.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000108604 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000078619 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (Nov 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev. 10 (17): 2117–30. doi:10.1101/gad.10.17.2117. PMID 8804307.
  6. Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (Sep 1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome". Genomics. 51 (1): 140–3. doi:10.1006/geno.1998.5343. PMID 9693044.
  7. "Entrez Gene: SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2".

Further reading


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