SMG7

SMG7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YA0
Identifiers
Aliases	SMG7, C1orf16, EST1C, SGA56M, nonsense mediated mRNA decay factor, SMG7 nonsense mediated mRNA decay factor
External IDs	OMIM: 610964 MGI: 2682334 HomoloGene: 32235 GeneCards: SMG7
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	183,598,246 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	152,778,397 bp[2]
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; right uterine tube; ; islet of Langerhans; ; ganglionic eminence; ; postcentral gyrus; ; cerebellar cortex; ; cerebellar hemisphere; ; Brodmann area 10; ; sural nerve; ; sperm;
	Top expressed in
	ascending aorta; ; aortic valve; ; blood; ; hand; ; cumulus cell; ; interventricular septum; ; morula; ; pineal gland; ; visual cortex; ; renal corpuscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase 2A binding; protein binding; telomeric DNA binding; ribonuclease activity; ribonucleoprotein complex binding; telomerase RNA binding;
Cellular component	cytoplasm; intermediate filament cytoskeleton; nucleus; telomerase holoenzyme complex; cytosol;
Biological process	regulation of dephosphorylation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; telomere maintenance via telomerase; regulation of RNA stability; RNA phosphodiester bond hydrolysis; regulation of telomere maintenance via telomerase;
	Sources:Amigo / QuickGO
Orthologs
	9887
	226517
	ENSG00000116698
	ENSMUSG00000042772
	Q92540
	Q5RJH6
NM_001174061; NM_014837; NM_173156; NM_201568; NM_201569;
	NM_001331007; NM_001350219; NM_001350220; NM_001350221; NM_001350222; NM_001375584; NM_001375585
	NM_001005507; NM_001160256; NM_001160257; NM_001359257
NP_001167532; NP_001317936; NP_775179; NP_963862; NP_963863;
	NP_001337148; NP_001337149; NP_001337150; NP_001337151; NP_001362513; NP_001362514
	NP_001005507; NP_001153728; NP_001153729; NP_001346186
	Wikidata
View/Edit Human	View/Edit Mouse

Protein SMG7 is a protein that in humans is encoded by the SMG7 gene.[5][6][7][8]

References

GRCh38: Ensembl release 89: ENSG00000116698 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000042772 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, et al. (November 2003). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7". Molecular Cell. 12 (5): 1187–200. doi:10.1016/S1097-2765(03)00443-X. PMID 14636577.
Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E (February 2005). "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway". Molecular Cell. 17 (4): 537–47. doi:10.1016/j.molcel.2005.01.010. PMID 15721257.
"Entrez Gene: SMG7 Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)".
Yang L, Kraft VA, Pfeiffer S, Merl-Pham J, Bao X, An Y, et al. (June 2020). "Nonsense-mediated decay factor SMG7 sensitizes cells to TNFα-induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1". Molecular Oncology. 14 (10): 2420–2435. doi:10.1002/1878-0261.12754. PMC 7530794. PMID 32602581.

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, et al. (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, et al. (April 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
Reichenbach P, Höss M, Azzalin CM, Nabholz M, Bucher P, Lingner J (April 2003). "A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed". Current Biology. 13 (7): 568–74. doi:10.1016/S0960-9822(03)00173-8. PMID 12676087. S2CID 14423276.
Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L (April 2003). "Functional conservation of the telomerase protein Est1p in humans". Current Biology. 13 (8): 698–704. doi:10.1016/S0960-9822(03)00210-0. PMID 12699629. S2CID 6685276.
Unterholzner L, Izaurralde E (November 2004). "SMG7 acts as a molecular link between mRNA surveillance and mRNA decay". Molecular Cell. 16 (4): 587–96. doi:10.1016/j.molcel.2004.10.013. PMID 15546618.
Azzalin CM, Lingner J (February 2006). "The human RNA surveillance factor UPF1 is required for S phase progression and genome stability". Current Biology. 16 (4): 433–9. doi:10.1016/j.cub.2006.01.018. PMID 16488880. S2CID 17197870.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116698 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042772 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14636577-5] Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, et al. (November 2003). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7". Molecular Cell. 12 (5): 1187–200. doi:10.1016/S1097-2765(03)00443-X. PMID 14636577.

[pmid15721257-6] Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E (February 2005). "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway". Molecular Cell. 17 (4): 537–47. doi:10.1016/j.molcel.2005.01.010. PMID 15721257.

[entrez-7] "Entrez Gene: SMG7 Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)".

[8] Yang L, Kraft VA, Pfeiffer S, Merl-Pham J, Bao X, An Y, et al. (June 2020). "Nonsense-mediated decay factor SMG7 sensitizes cells to TNFα-induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1". Molecular Oncology. 14 (10): 2420–2435. doi:10.1002/1878-0261.12754. PMC 7530794. PMID 32602581.

SMG7

References

Further reading